LitCovid-sentences  

PMC:7212965 / 96092-98142 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T971 0-68 Sentence denotes Medication class Medication Sourcea Indirect GI adverse events Other
T972 69-132 Sentence denotes Nausea/vomiting Abdominal pain Diarrhea Jaundice Hepatotoxicity
T973 133-328 Sentence denotes Antiviral Lopinavir/ritonavir FDA/ manufacturer's label110 HIV Nausea (5%–16%); vomiting (children 21%; adults 2%–7%) Reported 1%–11% 7%–28%; greater with once-daily dosing — Increased serum ALT:
T974 329-380 Sentence denotes 1%–11%; hepatitis including AST/ALT/GGT elevations:
T975 381-574 Sentence denotes 4%; hyperbilirubinemia (children 3%; adults 1%) Dysgeusia (children 22%; adults <2%); hyperamylasemia (3%–8%), dyspepsia (<6%), increased lipase (3%–5%), flatulence (1-4%), gastroenteritis (3%)
T976 575-619 Sentence denotes NIH Liver Tox111 HIV Range from mild to ALF.
T977 620-642 Sentence denotes Recovery takes 1–2 mo.
T978 643-679 Sentence denotes Do not re-challenge with medication.
T979 680-715 Sentence denotes Monitor for exacerbation of HBV/HCV
T980 716-783 Sentence denotes Momattin,105 2019 MERS Prevalence of GI AEs not reported in this SR
T981 784-868 Sentence denotes Yao,106 2020 SARS/MERS AEs not reported in this SR (can check primary studies) SARS:
T982 869-931 Sentence denotes 2 retrospective cohort studies (combined with steroids); MERS:
T983 932-1060 Sentence denotes 1 RCT combined with IFN, 1 retrospective cohort combined with IFN/ribavirin, and 2 case reports also combined with IFN/ribavirin
T984 1061-1095 Sentence denotes Remdesivir Al-Tawfiq,107 2020 MERS
T985 1096-1117 Sentence denotes Sheahan,108 2020 MERS
T986 1118-1392 Sentence denotes Antimalarial Chloroquine FDA/ manufacturer's label/NIH Liver Tox111,112 Malaria Reported; frequency not defined Abdominal cramps reported; frequency not defined Reported; frequency not defined Rarely linked to aminotransferase elevations or clinically apparent liver injury.
T987 1393-1605 Sentence denotes In patients with AIP or PCT, it can trigger an attack with fever and serum aminotransferase elevations, sometimes resulting in jaundice Minor metabolism by liver (∼30%); mostly excreted in urine Likelihood score:
T988 1606-1665 Sentence denotes D (possible rare cause of clinically apparent liver injury)
T989 1666-1990 Sentence denotes Hydroxychloroquine113 FDA / Manufacturer's label Malaria / SLE Reported; frequency not defined Reported; frequency not defined Reported; frequency not defined Same as chloroquine above; can be exchanged with chloroquine as most reactions are hypersensitivity and no known cross reactivity to hepatic injury Likelihood score:
T990 1991-2050 Sentence denotes D (possible rare cause of clinically apparent liver injury)