LitCovid-sentences  

PMC:7212965 / 48043-53055 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T321 0-39 Sentence denotes Evidence Gaps and Guidance for Research
T322 40-256 Sentence denotes There is insufficient evidence on the impact of COVID-19 on subgroups of patients, such as patients with inflammatory bowel disease, chronic liver disease, or liver transplant recipients on chronic immunosuppression.
T323 257-596 Sentence denotes Early data do not indicate excess risk among patients with inflammatory bowel disease.94, 95, 96, 97, 98 A number of international registries have been established that will provide extremely valuable information about COVID-19 in these potentially vulnerable populations (www.covidibd.org; covidcirrhosis.web.unc.edu; www.gi-covid19.org).
T324 597-718 Sentence denotes Other clinical decisions, including optimal medication management and treatment decisions, are still under investigation.
T325 719-834 Sentence denotes We encourage clinicians to contribute to these registries to further enhance understanding in these subpopulations.
T326 835-954 Sentence denotes Table 4 provides guidance for future studies of GI manifestations in patients with COVID-19 or other similar pathogens.
T327 955-1031 Sentence denotes Table 4 Guidance and Research Considerations for Future Studies of COVID-19a
T328 1032-1251 Sentence denotes Study design A prospective inception cohort study is a favorable study design.Another study design that is informative especially when there is a need for rapid data evaluation is a retrospective inception cohort study.
T329 1252-1614 Sentence denotes Participants Enrollment of consecutive patients beginning at pandemic onset.Specific set of symptoms that are predictive of COVID-19 infection, all symptoms should be systematically collected on presentation and before COVID-19 diagnosis is established.• Elicit typical upper respiratory infection symptoms (eg, cough, shortness of breath, chest pain, and fever)
T330 1615-1783 Sentence denotes • Inquire about less typical symptoms, such as GI-specific symptoms: diarrhea, nausea, vomiting, and abdominal pain, and also other symptoms, such as anosmia, dysguesia
T331 1784-1966 Sentence denotes • Describe the GI symptoms in detail, including initial vs late, concurrent vs isolated, duration and frequency, history, and medication initiation relating to the onset of symptoms.
T332 1967-2072 Sentence denotes Investigators should avoid:• Undefined sampling (convenience sampling), including undefined time periods.
T333 2073-2230 Sentence denotes • Overlap of the same population with other publications, which can be done by coordinating efforts between the different departments within the institution.
T334 2231-2419 Sentence denotes Investigators should consider stratification for GI comorbidities, such as inflammatory bowel disease and cirrhosisInvestigators should consider stratification by outpatients vs inpatients
T335 2420-3258 Sentence denotes Laboratory Standardized laboratory confirmation should be based on nucleic acid amplification testing for SARS-CoV-2 on respiratory specimen rather than relying on radiologic suspicion on imaging studies, which are less specificLFTs should be obtained on admission and followed throughout the hospitalization.Changes in LFTs should be reported as normal/abnormal and the cutoff for abnormal should be specified, rather than mean and median at the individual patient levelPattern of LFTs abnormalities, hepatocellular vs cholestatic, should be reported as well as the evaluation performed to work up the abnormalitiesBaseline LFTs (prior to developing COVID-19), changes during the duration of the disease, and after resolution should be reported.Report stool RNA testing, when available, and presence of GI symptoms at the time of testing
T336 3259-3447 Sentence denotes Disease severity Use of standardized disease severity definitions, for example, as per World Health Organization–China Joint Mission100:• mild-to-moderate: non-pneumonia and mild pneumonia
T337 3448-3540 Sentence denotes • severe defined as tachypnea, oxygen saturation ≤93% at rest, or PaO2/FiO2 ratio <300 mm Hg
T338 3541-3686 Sentence denotes • critical respiratory failure requiring mechanical ventilation, septic shock, or other organ dysfunction or failure that requires intensive care
T339 3687-3763 Sentence denotes Patients can be stratified by:• Disease severity and presence of GI symptoms
T340 3764-3791 Sentence denotes • Disease severity and LFTs
T341 3792-3890 Sentence denotes Symptoms and their duration before development of a severe stage of the disease should be reported
T342 3891-4177 Sentence denotes Outcomes Outcomes should focus on patient-important outcomes, such as death, clinical improvement or disease worsening/progression, hospital discharge; include clinical definitions (eg, threshold reached for intubation); select sufficient follow-up time to ensure outcome is obtainable.
T343 4178-4419 Sentence denotes Analysis Analysis should attempt to control for confounding variables; analysis of risk factors should include univariate followed by multivariate analyses to identify independent risk factors predicting more severe disease and poor outcomes
T344 4420-4617 Sentence denotes a aIn the table, we specifically refer to COVID-19, but this guidance applies to any future pathogen similar to COVID-19 that presents as a viral illness with potential GI and liver manifestations.
T345 4618-4700 Sentence denotes Finally, peer-review remains critical to the process of disseminating information.
T346 4701-5012 Sentence denotes Journals should add resources to expedite reviews by increasing the number of editors and reviewers to shorten the review process; maintain accuracy, high quality, and details of the data reported; as well as to avoid overlap in patients between studies or multiple studies being published on the same cohort.99