LitCovid-sentences  

PMC:7212965 / 44330-47454 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T297 0-108 Sentence denotes Limitations of the Evidence on Gastrointestinal and Liver Manifestations in Patients With COVID-19 Infection
T298 109-174 Sentence denotes The individual studies in our analysis were at high risk of bias.
T299 175-316 Sentence denotes The majority of studies reported on cohorts of patients based on inclusion dates and did not specify whether these were consecutive patients.
T300 317-518 Sentence denotes There was an inconsistent assessment of symptoms and/or laboratory tests with missing data, and none of the studies reported whether patients were systematically evaluated for GI symptoms on admission.
T301 519-609 Sentence denotes Most studies did not report on the duration of the GI symptoms preceding the presentation.
T302 610-814 Sentence denotes When GI symptoms were reported, it was difficult to discern whether these were isolated symptoms or whether patients also had concurrent typical COVID-19 symptoms (eg, fever cough or shortness of breath).
T303 815-933 Sentence denotes LFTs were mostly reported as the mean/median value of the entire cohort and without cutoff values for the institution.
T304 934-1012 Sentence denotes Many of the studies did not report on underlying chronic GI or liver diseases.
T305 1013-1152 Sentence denotes There was a lot of heterogeneity in our pooled estimates that could not be explained by our subgroup analysis based on geographic location.
T306 1153-1348 Sentence denotes Lastly, the data on prognosis were especially difficult to analyze due to insufficient follow-up of the patients (the majority of the patients were still hospitalized at the time of publication).
T307 1349-1514 Sentence denotes Finally, there was no stratification of GI-related symptoms and severity of COVID-19 or patient important outcomes, such as need for intensive care unit or survival.
T308 1515-1589 Sentence denotes There may be additional limitations of our findings based on our analysis.
T309 1590-1794 Sentence denotes Due to concerns about overlapping cohorts, we used a hierarchical framework to identify unique cohorts based on the number of patients and the hospitals to analyze the prevalence of GI and liver symptoms.
T310 1795-1964 Sentence denotes It is possible that we excluded relevant studies that provided more granularity regarding the GI and liver manifestations, or had more systematic assessment of outcomes.
T311 1965-2058 Sentence denotes As a result, this may have led to an over- or underestimation of the pooled effect estimates.
T312 2059-2267 Sentence denotes However, we have high confidence that we were able to eliminate the counting of some patients in more than 1 report by using our selection framework, unless they were transferred from one hospital to another.
T313 2268-2369 Sentence denotes An important strength of this study is the appropriate statistical analysis used to pool proportions.
T314 2370-2611 Sentence denotes We also reviewed gray literature from prepublication repositories, which allowed us to include a large number of studies that have not been published yet, with data from a total of 10,890 unique COVID-19 patients being included in this work.
T315 2612-2838 Sentence denotes Lastly, we tried to narratively describe studies that informed us on the type of diarrhea symptoms; whether diarrhea was reported as the only presenting symptom; or diarrhea as the initial symptom that preceded other symptoms.
T316 2839-3124 Sentence denotes Based on our study selection process, we may have missed studies, including smaller case series that reported on this information, and studies that were published after our inclusion period, in light of the exponential number of studies in press, under review, and on preprint servers.