| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T237 |
0-377 |
Sentence |
denotes |
Both chloroquines have reported infrequent Gl adverse effects (ie, nausea, vomiting, abdominal pain, and diarrhea).84 , 85 The National Institute of Health LiverTox resource rates both drugs with a likelihood score of D (possible rare cause of clinically apparent liver injury).86 Chloroquine is rarely linked to aminotransferase elevations or clinically apparent liver injury. |
| T238 |
378-575 |
Sentence |
denotes |
In patients with acute intermittent porphyria or porphyria cutanea tarda, it can trigger a hypersensitivity attack with fever and serum aminotransferase elevations, sometimes resulting in jaundice. |
| T239 |
576-627 |
Sentence |
denotes |
This is seen less commonly with hydroxychloroquine. |
| T240 |
628-787 |
Sentence |
denotes |
Such reactions are thought to be hypersensitivity reactions and there is no known cross-reactivity in liver injury between hydroxychloroquine and choloroquine. |
| T241 |
788-975 |
Sentence |
denotes |
Hydroxychloroquine is known to concentrate in the liver, thus patients with hepatitis or other hepatic diseases, or patients taking other known hepatotoxic drugs, should exercise caution. |
| T242 |
976-1112 |
Sentence |
denotes |
In addition, cardiac conduction defects leading to clinically relevant arrhythmias are an important adverse effect of these medications. |
