| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T234 |
0-24 |
Sentence |
denotes |
Antimalarial Medications |
| T235 |
25-336 |
Sentence |
denotes |
Although efficacy and subsequent optimal dosing in COVID-19 is still under investigation, both chloroquine and hydroxychloroquine are currently FDA-approved in the United States for other indications (ie, malaria and systemic lupus erythematosus) and now have an emergency use authorization for use in COVID-19. |
| T236 |
338-372 |
Sentence |
denotes |
Chloroquine and hydroxychloroquine |
| T237 |
373-750 |
Sentence |
denotes |
Both chloroquines have reported infrequent Gl adverse effects (ie, nausea, vomiting, abdominal pain, and diarrhea).84 , 85 The National Institute of Health LiverTox resource rates both drugs with a likelihood score of D (possible rare cause of clinically apparent liver injury).86 Chloroquine is rarely linked to aminotransferase elevations or clinically apparent liver injury. |
| T238 |
751-948 |
Sentence |
denotes |
In patients with acute intermittent porphyria or porphyria cutanea tarda, it can trigger a hypersensitivity attack with fever and serum aminotransferase elevations, sometimes resulting in jaundice. |
| T239 |
949-1000 |
Sentence |
denotes |
This is seen less commonly with hydroxychloroquine. |
| T240 |
1001-1160 |
Sentence |
denotes |
Such reactions are thought to be hypersensitivity reactions and there is no known cross-reactivity in liver injury between hydroxychloroquine and choloroquine. |
| T241 |
1161-1348 |
Sentence |
denotes |
Hydroxychloroquine is known to concentrate in the liver, thus patients with hepatitis or other hepatic diseases, or patients taking other known hepatotoxic drugs, should exercise caution. |
| T242 |
1349-1485 |
Sentence |
denotes |
In addition, cardiac conduction defects leading to clinically relevant arrhythmias are an important adverse effect of these medications. |
