| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T107 |
0-527 |
Sentence |
denotes |
A total of 57 studies were ultimately selected for complete data extraction; 56 from our search and 1 additional manuscript (under review) was included to provide more data on a US cohort20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76 (see Supplementary Figure 1 for Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram). |
| T108 |
528-666 |
Sentence |
denotes |
Of the 57 selected studies, 47 reported on unique patients based on hospital name (with no duplication of cohorts from the same hospital). |
| T109 |
667-974 |
Sentence |
denotes |
An additional 10 studies were identified with potentially overlapping cohorts based on hospital name, but these were included if they provided unique information about a specific symptom (eg, diarrhea at initial presentation when the larger cohort did not clearly state that it was at initial presentation). |
| T110 |
975-1110 |
Sentence |
denotes |
Based on our comprehensive selection process, we believe that the included 47 studies reported data on 10,890 unique COVID-19 patients. |
| T111 |
1111-1273 |
Sentence |
denotes |
The majority of studies (70%) in our analysis were from China; these were selected from 118 reports published or prepublished from China (Supplementary Figure 2). |
| T112 |
1274-1383 |
Sentence |
denotes |
The studies included mainly adults, although a few studies included a small proportion of pediatric patients. |
| T113 |
1384-1551 |
Sentence |
denotes |
Two studies reported on outpatients only, whereas the remaining 55 studies reported on hospitalized patients or a combination of outpatients and hospitalized patients. |
| T114 |
1552-1584 |
Sentence |
denotes |
Based on our inclusion strategy: |
| T115 |
1585-1703 |
Sentence |
denotes |
55 studies (96%) provided information on any GI symptom and 32 studies (56%) reported any data on liver abnormalities. |
| T116 |
1704-1778 |
Sentence |
denotes |
Fewer studies, 21 (37%), provided information on underlying GI conditions. |
| T117 |
1779-1841 |
Sentence |
denotes |
Table 2 provides a summary of the pooled prevalence estimates. |
| T118 |
1842-1933 |
Sentence |
denotes |
Table 2 Summary of the Pooled Prevalence Estimates of Gastrointestinal/Liver Manifestations |
| T119 |
1934-2032 |
Sentence |
denotes |
GI and liver manifestations All studies Studies from China Studies from countries other than China |
| T120 |
2033-2128 |
Sentence |
denotes |
% (95% CI) Patients/ studies, n % (95% CI) Patients/ studies, n % (95% CI) Patients/ studies, n |
| T121 |
2129-2234 |
Sentence |
denotes |
Diarrhea in all patientsa 7.7 (7.2 to 8.2) 43/10,676 5.8 (5.3 to 6.4) 32/8612 18.3 (16.6 to 20.1) 11/2064 |
| T122 |
2235-2345 |
Sentence |
denotes |
Nausea/vomiting in all patientsa 7.8 (7.1 to 8.5) 26/5955 5.2 (4.4 to 5.9) 19/4054 14.9 (13.3 to –16.6) 7/1901 |
| T123 |
2346-2451 |
Sentence |
denotes |
Abdominal pain in all patientsa 3.6 (3.0 to 4.3) 15/4031 2.7 (2.0 to 3.4) 10/2447 5.3 (4.2 to 6.6) 5/1584 |
| T124 |
2452-2560 |
Sentence |
denotes |
Patients with elevated AST 15.0 (13.6 to 16.5) 16/2514 14.9 (13.5 to 16.4) 14/2398 20.0 (12.8 to 28.1) 2/116 |
| T125 |
2561-2669 |
Sentence |
denotes |
Patients with elevated ALT 15.0 (13.6 to 16.4) 17/2711 14.9 (13.5 to 16.3) 15/2595 19.0 (12.0 to 27.1) 2/116 |
| T126 |
2670-2768 |
Sentence |
denotes |
Patients with elevated total bilirubin 16.7 (15.0 to 18.5) 10/1841 16.7 (15.0 to 18.5) 10/1841 — — |
| T127 |
2769-2824 |
Sentence |
denotes |
a Regardless of hospitalization and timing of symptoms. |
