LitCovid-sentences  

PMC:7212949 / 3190-11031 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T23 0-151 Sentence denotes We searched the published literature for multiple combinations of different organs, and names for infectious conditions of those organs and novel CoVs.
T24 152-235 Sentence denotes We only included articles written in the English language and published after 2002.
T25 236-287 Sentence denotes We included both animal and human research studies.
T26 288-344 Sentence denotes The search methodology resulted in nearly 2000 articles.
T27 345-459 Sentence denotes During the further review, we limited the number of articles by eliminating articles that lacked direct relevance.
T28 460-600 Sentence denotes We populated tables with disease manifestations in various organs (Table 1, Table 2, Table 3, Table 4, Table 5, Table 6, Table 7, Table 8 ).
T29 601-669 Sentence denotes Table 1 Pulmonary manifestations of SARS-CoV, MERS-CoV and COVID-19.
T30 670-726 Sentence denotes SARS (only studies with large study population included)
T31 727-974 Sentence denotes Study Lee et al (2003)N = 138, confirmed casesRetrospective study Lang et al (2003)N = 3, confirmed casesClinicopathologic study Liu et al (2004)N = 53, confirmed casesRetrospective study Peiris et al (2003)N = 75, confirmed casesProspective study
T32 975-1039 Sentence denotes Clinical features • Preexisting chronic pulmonary disease (2.1%)
T33 1040-1054 Sentence denotes • Fever (100%)
T34 1055-1070 Sentence denotes • Cough (57.3%)
T35 1071-1085 Sentence denotes • Sputum (29%)
T36 1086-1122 Sentence denotes • Sore throat (23.2%) Coryza (22.5%)
T37 1123-1246 Sentence denotes • Inspiratory crackles Fever (3/3)Dyspnea (3/3)Mildly productive cough (1/3)Death within 9-15 days of illness • Fever (98%)
T38 1247-1329 Sentence denotes • Cough (68% on admission to isolation, 74% after hospitalization, 26% productive)
T39 1330-1362 Sentence denotes 4.5 ± 1.9 days after fever onset
T40 1363-1404 Sentence denotes • Dyspnea (40% on admission to isolation)
T41 1405-1542 Sentence denotes • O2 saturation <90% on room air (51% on hospitalization, 11% on admission to isolation) • Fever (100%), recurred in 85% at mean 8.9 days
T42 1543-1556 Sentence denotes • Cough (29%)
T43 1557-1611 Sentence denotes • Spontaneous pneumomediastinum (12%) during follow-up
T44 1612-1631 Sentence denotes • Sore throat (11%)
T45 1632-1658 Sentence denotes • Shortness of breath (4%)
T46 1659-1730 Sentence denotes • O2 saturation < 90% on room air (44mean 9.1 days after symptom onset)
T47 1731-1820 Sentence denotes Key findings on investigations CXR• Consolidation (78.3% at fever onset, eventually 100%)
T48 1821-1846 Sentence denotes • 54.6% unilateral, focal
T49 1847-1878 Sentence denotes • 45.4% multifocal or bilateral
T50 1879-1908 Sentence denotes • Peripheral zone predominant
T51 1909-2001 Sentence denotes CT• Progression of chest CT infiltrates 7-10 days after admission, resolution with treatment
T52 2002-2069 Sentence denotes • lll-defined peripheral GGO, usually subpleural • Leukopenia (2/3)
T53 2070-2089 Sentence denotes • Lymphopenia (2/3)
T54 2090-2096 Sentence denotes • CXR:
T55 2097-2178 Sentence denotes Bilateral interstitial infiltrates • Abnormal CXR (59% on admission, 98% anytime)
T56 2179-2240 Sentence denotes • 63% patients – first unifocal infiltrates at 4.5 ± 2.1 days
T57 2241-2349 Sentence denotes • 37% patients - started as multifocal infiltrates at 5.8 ± 1.3 days after fever onset Initial CXR abnormal:
T58 2350-2369 Sentence denotes 71%• One lung zone:
T59 2370-2373 Sentence denotes 49%
T60 2374-2387 Sentence denotes • Multizonal:
T61 2388-2391 Sentence denotes 21%
T62 2392-2432 Sentence denotes Chest CT abnormal (55% of 33)• One lobe:
T63 2433-2436 Sentence denotes 55%
T64 2437-2450 Sentence denotes • Multilobar:
T65 2451-2454 Sentence denotes 46%
T66 2455-2490 Sentence denotes • Focal ground-glass opacification:
T67 2491-2494 Sentence denotes 24%
T68 2495-2511 Sentence denotes • Consolidation:
T69 2512-2515 Sentence denotes 36%
T70 2516-2523 Sentence denotes • Both:
T71 2524-2527 Sentence denotes 39%
T72 2528-2572 Sentence denotes Radiologic worsening in 80% at mean 7.4 days
T73 2573-2596 Sentence denotes Histopathology • Gross:
T74 2597-2615 Sentence denotes Lung consolidation
T75 2616-2630 Sentence denotes • Early phase:
T76 2631-2678 Sentence denotes Pulmonary edema with hyaline membrane formation
T77 2679-2698 Sentence denotes • Organizing phase:
T78 2699-2750 Sentence denotes Cellular fibromyxoid organizing exudates in alveoli
T79 2751-2795 Sentence denotes • Scanty lymphocytic interstitial infiltrate
T80 2796-2839 Sentence denotes • Vacuolated and multinucleated pneumocytes
T81 2840-2881 Sentence denotes • Viral inclusions not detected. • Gross:
T82 2882-2916 Sentence denotes Diffuse hemorrhage on lung surface
T83 2917-3040 Sentence denotes • Serous, fibrinous and hemorrhagic inflammation in alveoli with desquamation of pneumocytes and hyaline-membrane formation
T84 3041-3133 Sentence denotes • Capillary engorgement and capillary microthrombosis, thromboemboli in bronchial arterioles
T85 3134-3203 Sentence denotes • Hemorrhagic necrosis lymphocyte depletion in lymph nodes and spleen
T86 3204-3311 Sentence denotes • Viral RNA detected in type II alveolar cells, interstitial cells and bronchiolar epithelial cells N/A N/A
T87 3312-3381 Sentence denotes Key study findings and message • 23.2% ICU admission, at day 6 (mean)
T88 3382-3417 Sentence denotes • 13.8% mechanical ventilation rate
T89 3418-3445 Sentence denotes • 3.6% crude mortality rate
T90 3446-3612 Sentence denotes • ICU patients more likely to be of older age (P = 0.009) Severe immunological damage to lung tissue causes clinical features • Fever most common and earliest symptom
T91 3613-3691 Sentence denotes • 23% mechanical ventilation rate • 83.33% of patients with GGO developed ARDS
T92 3692-3720 Sentence denotes • 20% mechanical ventilation
T93 3721-3740 Sentence denotes • 17% ICU admission
T94 3741-3838 Sentence denotes • Recurrence of fever (univariate) and age (multivariate) risk factors for ARDS and ICU admission
T95 3839-3843 Sentence denotes MERS
T96 3844-4112 Sentence denotes Study Assiri et al (2013)N = 47, confirmed casesRetrospective study Arabi et al (2014)N = 12, (11 confirmed cases, 1 probable)Case series Al-Abdley et al (2019)N = 33, confirmed casesRetrospective study Almekhlafi et al (2016)N = 31, confirmed casesRetrospective study
T97 4113-4171 Sentence denotes Clinical features • Preexisting chronic lung disease (26%)
T98 4172-4187 Sentence denotes • Smokers (23%)
T99 4188-4201 Sentence denotes • Fever (98%)
T100 4202-4215 Sentence denotes • Cough (83%)
T101 4216-4227 Sentence denotes • Dry (47%)
T102 4228-4246 Sentence denotes • Productive (36%)
T103 4247-4262 Sentence denotes • Dyspnea (72%)
T104 4263-4282 Sentence denotes • Sore throat (21%)
T105 4283-4340 Sentence denotes • Rhinorrhea (4%) • Preexisting chronic lung disease (8%)
T106 4341-4356 Sentence denotes • Dyspnea (92%)
T107 4357-4370 Sentence denotes • Cough (83%)
T108 4371-4384 Sentence denotes • Fever (67%)
T109 4385-4401 Sentence denotes • Wheezing (17%)
T110 4402-4426 Sentence denotes • Productive cough (17%)
T111 4427-4444 Sentence denotes • Rhinorrhea (8%)
T112 4445-4462 Sentence denotes • Hemoptysis (8%)
T113 4463-4522 Sentence denotes • Sore throat (8%) • Preexisting chronic lung disease (12%)
T114 4523-4538 Sentence denotes • Fever (75.7%)
T115 4539-4552 Sentence denotes • Cough (72%)
T116 4553-4568 Sentence denotes • Dyspnea (59%)
T117 4569-4588 Sentence denotes • Sore throat (12%)
T118 4589-4619 Sentence denotes Rhinorrhea (9%) • Cough (100%)
T119 4620-4638 Sentence denotes • Tachypnea (100%)
T120 4639-4654 Sentence denotes • Fever (87.1%)
T121 4655-4676 Sentence denotes • Sore throat (25.8%)
T122 4677-4696 Sentence denotes • Crackles (93.5 %)
T123 4697-4713 Sentence denotes Rhonchi (32.3 %)
T124 4714-4863 Sentence denotes Key findings on investigations CXR abnormality (100%) – ARDS pattern CXR, CT: lobular to bilateral extensive ARDS pattern N/A CXR abnormality (96.4%)
T125 4864-4914 Sentence denotes Key study findings and message • 89% ICU admission
T126 4915-4943 Sentence denotes • 72% mechanical ventilation
T127 4944-5110 Sentence denotes • 60% case fatality rate 100% invasive mechanical ventilation, mean duration 100 days • Dyspnea before admission was associated with a more severe outcome (P < 0.001)
T128 5111-5220 Sentence denotes Prolonged MERS-CoV detection in URT in diabetics (P = 0.049) • 87.1 % invasive mechanical ventilation (87.1%)
T129 5221-5255 Sentence denotes • 74.2% overall ICU mortality rate
T130 5256-5335 Sentence denotes • Mortality in ICU associated with older age, severe disease and organ failure.
T131 5336-5344 Sentence denotes COVID-19
T132 5345-5598 Sentence denotes Study Huang et al (2020)N = 41, confirmed casesRetrospective study Wang et al (2020)N = 138, confirmed casesRetrospective study Guan et al (2020)N = 1099, confirmed casesRetrospective study Zhang et al (2020)N = 1, confirmed casesClinicopathologic study
T133 5599-5630 Sentence denotes Clinical features • Smoker (7%)
T134 5631-5654 Sentence denotes • Preexisting COPD (2%)
T135 5655-5666 Sentence denotes • Fever 98%
T136 5667-5684 Sentence denotes • Dry cough (76%)
T137 5685-5725 Sentence denotes • Dyspnea (55%), mean 8 days after onset
T138 5726-5740 Sentence denotes • Sputum (28%)
T139 5741-5758 Sentence denotes • Hemoptysis (5%)
T140 5759-5796 Sentence denotes • ARDS (29%), mean 9 days after onset
T141 5797-5842 Sentence denotes • ↑RR >24/min (29%) • Preexisting COPD (2.9%)
T142 5843-5856 Sentence denotes • Fever 98.6%
T143 5857-5875 Sentence denotes • Dry cough (59.4)
T144 5876-5892 Sentence denotes • Sputum (26.8%)
T145 5893-5927 Sentence denotes • Dyspnea, mean 5 days after onset
T146 5928-6014 Sentence denotes • ARDS (19.6%), mean 8 days after onset • Preexisting chronic pulmonary disease (1.1%)
T147 6015-6073 Sentence denotes • Fever (43.8% on admission, 88.7% during hospitalization)
T148 6074-6089 Sentence denotes • Cough (67.8%)
T149 6090-6106 Sentence denotes • Sputum (33.7%)
T150 6107-6128 Sentence denotes • Sore throat (13.9%)
T151 6129-6154 Sentence denotes • Nasal congestion (4.8%)
T152 6155-6174 Sentence denotes • Hemoptysis (0.9%)
T153 6175-6188 Sentence denotes • ARDS (3.4%)
T154 6189-6214 Sentence denotes • 1.4% case fatality rate
T155 6215-6256 Sentence denotes • 4 days median incubation period • Fever
T156 6257-6264 Sentence denotes • Cough
T157 6265-6318 Sentence denotes • ARDS requiring mechanical ventilation within 1 week
T158 6319-6399 Sentence denotes Key findings on investigations Abnormal chest CT (100%); (98% bilateral) • ↓PaO2
T159 6400-6435 Sentence denotes • ↓PaO2:FiO2 • Abnormal CXR (59.1%)
T160 6436-6463 Sentence denotes • Abnormal Chest CT (86.2%)
T161 6464-6506 Sentence denotes • Ground glass opacity most common (56.4%)
T162 6507-6610 Sentence denotes • No lung imaging findings in 17.9% patients with nonsevere disease and in 2.9% with severe disease CT:
T163 6611-6650 Sentence denotes Patchy bilateral ground glass opacities
T164 6651-6809 Sentence denotes Histopathology N/A N/A N/A • Diffuse alveolar damage with organizing changes of fibrous plugs, with interstitial fibrosis and chronic inflammatory infiltrates
T165 6810-6871 Sentence denotes • Denuded alveolar lining with pneumocyte type II hyperplasia
T166 6872-6967 Sentence denotes • Virus detected on alveolar epithelial cells including desquamated cells, not in blood vessels
T167 6968-7045 Sentence denotes Key study findings and message • ICU patients had more areas of consolidation
T168 7046-7107 Sentence denotes • 10% mechanical ventilation rate, mean 10.5 days after onset
T169 7108-7236 Sentence denotes • 5% ECMO rate • High-flow O2 therapy in 11.1% ICU patients, noninvasive ventilation in 41.7%, and invasive ventilation in 47.2%
T170 7237-7353 Sentence denotes • Older patients (P < 0.001), patients with more comorbidities, dyspnea and anorexia more likely to require ICU care
T171 7354-7366 Sentence denotes • Mortality:
T172 7367-7410 Sentence denotes 4.3% • Mechanical ventilation needed (6.1%)
T173 7411-7517 Sentence denotes • Radiographic abnormalities often absent Histopathologic findings consistent with diffuse alveolar damage
T174 7518-7841 Sentence denotes ARDS, acute respiratory distress syndrome; CXR, chest x-ray; ECMO, extracorporeal membrane oxygenation; GGO, ground glass opacities; ICU, intensive care unit; MERS-CoV, middle east respiratory syndrome coronavirus; RR, respiratory rate; SARS-COV, severe acute respiratory syndrome coronavirus; URT, upper respiratory tract.