LitCovid-sentences  

PMC:7211620 / 1775-6569 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T19 0-7 Sentence denotes 2 Case
T20 8-88 Sentence denotes Here we report a 70-year-old male who was diagnosed with COVID-19 in March 2020.
T21 89-455 Sentence denotes Underlying diseases included chronic obstructive pulmonary disease (COPD) GOLD grade 2, obstructive sleep apnea syndrome, insulin-dependent type 2 diabetes with end-organ damage [retinopathy, nephropathy (CKD 3b according to the KDIGO classification at first presentation), polyneuropathy], arterial hypertension, coronary heart disease and obesity (body mass index:
T22 456-466 Sentence denotes 38 kg/m2).
T23 467-561 Sentence denotes Past medical history included proximal deep vein thrombosis four months prior to presentation.
T24 562-825 Sentence denotes His medication consisted of a long-acting beta agonist/long-acting muscarinic antagonist combination, inhaled glucocorticoid (400 μg budesonide per day), valsartan, spironolactone, ivabradine, atorvastatin, metformin, liraglutide, insulin glargine and enoxaparin.
T25 826-936 Sentence denotes The patient presented with productive cough, dyspnea and intermittent fever (>38.5 °C) for one week (Fig. 1 ).
T26 937-990 Sentence denotes Arterial pO2 was 67 mmHg while breathing ambient air.
T27 991-1134 Sentence denotes White blood cell count was within the normal limits and C-reactive protein (CRP) was slightly elevated (33 mg/dl; upper limit of norm 5 mg/dl).
T28 1135-1171 Sentence denotes D-dimer was within the normal range.
T29 1172-1253 Sentence denotes Chest X-ray revealed bilateral basal coarse reticular opacities (Fig. 2 a and b).
T30 1254-1348 Sentence denotes Real-time polymerase chain reaction (PCR) from oropharyngeal swab was positive for SARS-CoV-2.
T31 1349-1478 Sentence denotes However, the patient refused to be hospitalized due to personal reasons and was discharged home with oral doxycycline 200 mg q.d.
T32 1479-1643 Sentence denotes One week later, the patient returned to the emergency department because of clinical deterioration and hypoxemia (arterial pO2 46 mmHg while breathing ambient air).
T33 1644-1766 Sentence denotes Chest CT-scan was performed and showed multiple bilateral ground-glass opacities with a crazy paving appearance (Fig. 2c).
T34 1767-1825 Sentence denotes In addition, a reversed halo sign was described (Fig. 2d).
T35 1826-2015 Sentence denotes White blood-cell count was slightly elevated (11.65 × 10^9 per L), neutrophils were elevated (9.7 × 10^9 per L), CRP level was 144 mg/dl, interleukin-6 was 396 pg/ml and ferritin 465 ng/ml.
T36 2016-2095 Sentence denotes Creatinine levels increased from 1.85 mg/dl (first presentation) to 3.26 mg/dl.
T37 2096-2137 Sentence denotes Lymphocytes were within the normal range.
T38 2138-2313 Sentence denotes The patient was admitted to ICU with moderate ARDS (oxygenation index 154) and received meropenem 1 g b.i.d., azithromycin 500mg once q.d., and hydroxychloroquine 200mg b.i.d.
T39 2314-2359 Sentence denotes He was intubated and mechanically ventilated.
T40 2360-2530 Sentence denotes Chest X-ray revealed a progression of the bilateral infiltrates on day 2 after ICU admission concordant with significant pulmonary deterioration (oxygenation index <100).
T41 2531-2622 Sentence denotes On day 3 of ICU stay (day 14 after onset of symptoms) endotracheal aspiration was obtained.
T42 2623-2743 Sentence denotes Culture grew Aspergillus fumigatus (voriconazole minimal inhibitory concentration 0.125 mg/L), without bacterial growth.
T43 2744-2979 Sentence denotes Aspergillus lateral-flow device (LFD) [3], detecting an Aspergillus specific antigen secreted during active growth of Aspergillus and not during colonization, was performed from the endotracheal aspirate and revealed a positive result.
T44 2980-3074 Sentence denotes Due to low sample volume, galactomannan could not be performed from this respiratory specimen.
T45 3075-3152 Sentence denotes Serum fungal biomarkers (galactomannan and 1,3-ß-D-glucan) remained negative.
T46 3153-3538 Sentence denotes Based on progression of pulmonary infiltrates, recovery of Aspergillus fumigatus in endotracheal aspirate, positive LFD in endotracheal aspirate and the clinical deterioration the patient was diagnosed with putative invasive pulmonary aspergillosis according to Blot et al. [4] and intravenous voriconazole (6 mg/kg b.i.d followed by 4 mg/kg b.i.d.) was initiated on day 4 of ICU stay.
T47 3539-3689 Sentence denotes Despite treatment of ICU and addition of voriconazole, the patient deceases 3 days after initiation of antifungal treatment due to multiorgan failure.
T48 3690-3716 Sentence denotes Autopsy was not performed.
T49 3717-3792 Sentence denotes Fig. 1 Timeline representing the course of COVID-19 in the reported patient
T50 3793-4074 Sentence denotes Abbreviations: q.d. = once daily; b.i.d. = twice daily, i.v. = intravenous; LFD = lateral-flow device; ER = emergency room; ARDS = acute respiratory distress syndrome; ICU = intensive care unit; SARS-CoV-2 = Severe acute respiratory syndrome coronavirus 2, CT = computed tomography
T51 4075-4097 Sentence denotes * Voriconazole dosage:
T52 4098-4160 Sentence denotes 6 mg/kg twice daily on day 1, followed by 4 mg/kg twice daily.
T53 4161-4235 Sentence denotes Chest imagings displayed here are also displayed in more detail in Fig. 2.
T54 4236-4330 Sentence denotes Fig. 2 Fig. 2a and b representing findings on chest X-ray performed on day 6 of symptom onset.
T55 4331-4439 Sentence denotes The lateral chest view revealed bilateral dorsal and basal coarse reticular opacities, no pleural effusions.
T56 4440-4509 Sentence denotes Fig. 2c and d representing chest CT scans on day 12 of symptom onset.
T57 4510-4794 Sentence denotes Axial CT image of the chest demonstrate extensive-ground glass opacities with bilateral and multi-lobar distribution (2c) and a combination of consolidation and surrounding ground-glass opacities basal in the posterior left lower lung (“reversed halo sign” - shown by the arrow) (2d).