LitCovid-sentences  

PMC:7205724 / 11460-14221 JSONTXT 20 Projects

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Id Subject Object Predicate Lexical cue
T96 0-41 Sentence denotes 4.1.2 Serum from bats with SARS-like CoV
T97 43-212 Sentence denotes 4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men
T98 213-389 Sentence denotes Genome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003.
T99 390-470 Sentence denotes Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12].
T100 471-558 Sentence denotes The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV.
T101 559-724 Sentence denotes RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14].
T102 725-902 Sentence denotes In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3].
T103 903-1056 Sentence denotes Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats.
T104 1058-1077 Sentence denotes 4.1.2.2 Rationale:
T105 1078-1134 Sentence denotes Bat serum is not able to efficiently neutralize SARS-CoV
T106 1135-1271 Sentence denotes The range of bats, belonging to the genus Rhinolophus (horseshoe bats) and the family Rhinolophidae, produce the SARS-CoV antibody [12].
T107 1272-1462 Sentence denotes Polymerase chain reaction (PCR) will confirm the presence of SARS-CoV nucleocapsid (N) and polymerase (P) proteins in fecal samples if an individual bat being seropositive for SARS-CoV [12].
T108 1463-1669 Sentence denotes There is a significant degree of resemblance of greater than 90% in the nucleotide sequence of the viral genomes between SL-CoV Rp3 [12] and the Tor2 strain of SARS-CoV – which was isolated in Toronto [15].
T109 1670-1882 Sentence denotes The differences in the genome sequences of SARS-CoV in the two species occur merely in the S gene – which encodes the S1 domain of the coronavirus spike protein and contains regions with high mutation rates [12].
T110 1883-2111 Sentence denotes The coronaviruses commonly possess five open reading frames (ORF) that correlate with the production of the replicase polyprotein (P), the spike (S), envelope (E), and membrane (M) glycoproteins and the nucleocapsid (N) protein.
T111 2112-2269 Sentence denotes The human SARS-CoV Tor2 and bat SL-CoV Rp3 strains remain more than 90% identical at the proteins P, E, M, and N. the protein S consists of two main domains:
T112 2270-2409 Sentence denotes 1) the S1 domain conveys the role of receptor binding and 2) the S2 domain assumes the role of the fusion of viral and host-cell membranes.
T113 2410-2544 Sentence denotes In particular, the human SARS-CoV Tor2 strain shows a noticeable degree of difference in the S1 domain from the bat SL-CoV Rp3 strain.
T114 2545-2761 Sentence denotes This diversity would suffice to produce functional differences between the species, and is an apparent reason why bat sera having high levels of cross-reactive antibodies not acted efficiently to neutralize SARS-CoV.