| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T69 |
0-125 |
Sentence |
denotes |
Just as for hydroxychloroquine, the pharmacokinetic parameters of azithromycin confirm these extreme distribution properties. |
| T70 |
126-280 |
Sentence |
denotes |
The volume of distribution of azithromycin was reported to be 31 L/kg and the half-life was 68 h, despite a relatively rapid clearance of 630 mL/min [18]. |
| T71 |
281-388 |
Sentence |
denotes |
Furthermore, the pharmacokinetics of azithromycin have been shown to be affected by the disease state [19]. |
| T72 |
389-538 |
Sentence |
denotes |
In a preclinical investigation, azithromycin was injected into rats and interstitial concentrations were measured in both thighs using microdialysis. |
| T73 |
539-591 |
Sentence |
denotes |
After 3 h, an infection was induced in only one leg. |
| T74 |
592-715 |
Sentence |
denotes |
Shortly after, the unbound interstitial tissue concentrations increased in the infected leg, without any additional dosing. |
| T75 |
716-849 |
Sentence |
denotes |
The results can be explained by macrophages loaded with lysosomal azithromycin migrating to and releasing drug at the infection site. |
