LitCovid-sentences  

PMC:7200337 / 96228-98521 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T554 0-90 Sentence denotes SARS-CoV-1 and SARS-CoV-2 consensus sequences share about 80% identity (Tai et al., 2020).
T555 91-260 Sentence denotes Thus, a wide range of SARS-CoV-1 nAbs have been tested for crossreactivity with SARS-CoV-2, as they could help speed up the development of potential COVID-19 treatments.
T556 261-386 Sentence denotes In a recent study, antibodies were isolated from the memory B cells of an individual who recovered from SARS-CoV-1 infection.
T557 387-540 Sentence denotes While 8 out of 25 isolated antibodies could bind SARS-CoV-2 S protein, one of them (s309; see Table 3 ) also neutralizes SARS-CoV-2 (Pinto et al., 2020).
T558 541-676 Sentence denotes The combination of s309 with a weakly neutralizing antibody that could bind another RBD epitope led to enhanced neutralization potency.
T559 677-830 Sentence denotes In addition, CR3022 (Table 3) was found to bind SARS-CoV-2 RBD (Tian et al., 2020b), but this antibody did not neutralize SARS-CoV-2 (Yuan et al., 2020).
T560 831-1045 Sentence denotes Computational simulations identified three amino acids that could be modified on CR3022 to enhance its binding affinity with SARS-CoV-2 RBD (Giron et al., 2020), potentially augmenting its neutralization potential.
T561 1046-1110 Sentence denotes Table 3 Strategies to Isolate SARS-CoV-2 Neutralizing Antibodies
T562 1111-1206 Sentence denotes Ab Source Clone Target Type of Antibody Neutralization Inhibition of ACE2/RBD Binding Reference
T563 1207-1294 Sentence denotes Derived from COVID-19 patients 31B532D4 RBD human monoclonal yes yes Chen et al., 2020a
T564 1295-1355 Sentence denotes P2C-2F6P2C-1F11 RBD human monoclonal yes yes Ju et al., 2020
T565 1356-1480 Sentence denotes Derived from SARS-CoV-1 patients CR3022 RBD human monoclonal no no Tian et al., 2020b, Yuan et al., 2020, Giron et al., 2020
T566 1481-1532 Sentence denotes S309 RBD human monoclonal yes no Pinto et al., 2020
T567 1533-1642 Sentence denotes Derived from SARS-CoV-1 or MERS-CoV-1 animal models R325R302R007 S1 rabbit monoclonal yes no Sun et al., 2020
T568 1643-1766 Sentence denotes 47D11 S1 recombinant human monoclonal (derived from hybridomas of immunized transgenic H2L2 mice) yes no Wang et al., 2020a
T569 1767-1841 Sentence denotes VHH-72-Fc S Fc-fusion derived from camelids VHH yes yes Wrapp et al., 2020
T570 1842-1917 Sentence denotes S polyclonal mouse antibodies yes N/A Walls et al., 2020, Yuan et al., 2020
T571 1918-1994 Sentence denotes Other ACE2-Fc RBD ACE2-Fc fusion yes N/A Lei et al., 2020a, Li et al., 2020d
T572 1995-2045 Sentence denotes RBD-Fc ACE2 RBD-Fc fusion yes N/A Li et al., 2020d
T573 2046-2144 Sentence denotes N3130 S1 human monoclonal single domain antibody isolated by phage display yes no Wu et al., 2020c
T574 2145-2220 Sentence denotes IVIg N/A polyclonal human IVIg N/A N/A Díez et al., 2020, Shao et al., 2020
T575 2221-2274 Sentence denotes F(ab′)2 RBD horse polyclonal yes N/A Pan et al., 2020
T576 2275-2293 Sentence denotes N/A, not assessed.