| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T417 |
96-310 |
Sentence |
denotes |
(A) Rdrp inhibitors (remdesivir, favipiravir), protease inhibitors (lopinavir/ritonavir), and antifusion inhibitors (arbidol) are currently being investigated in their efficacy in controlling SARS-CoV-2 infections. |
| T418 |
311-418 |
Sentence |
denotes |
(B) CQ and HCQ increase the pH within lysosomes, impairing viral transit through the endolysosomal pathway. |
| T419 |
419-567 |
Sentence |
denotes |
Reduced proteolytic function within lysosomes augments antigen processing for presentation on MHC complexes and increases CTLA4 expression on Tregs. |
| T420 |
568-703 |
Sentence |
denotes |
(C) Antagonism of IL-6 signaling pathway and of other cytokine-/chemokine-associated targets has been proposed to control COVID-19 CRS. |
| T421 |
704-824 |
Sentence |
denotes |
These include secreted factors like GM-CSF that contribute to the recruitment of inflammatory monocytes and macrophages. |
| T422 |
825-1041 |
Sentence |
denotes |
(D) Several potential sources of SARS-CoV-2 neutralizing antibodies are currently under investigation, including monoclonal antibodies, polyclonal antibodies, and convalescent plasma from recovered COVID-19 patients. |
| T423 |
1042-1177 |
Sentence |
denotes |
GM-CSF, granulocyte-macrophage colony-stimulating factor; CQ, chloroquine; HCQ, hydroxychloroquine; RdRp, RNA-dependent RNA polymerase. |
