LitCovid-sentences  

PMC:7200337 / 73069-75250 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T409 0-15 Sentence denotes RdRp Inhibitors
T410 16-204 Sentence denotes The CoV RNA-dependent RNA polymerase (RdRp) catalyzes the synthesis of viral RNA (Gao et al., 2020a), making it essential for viral replication and a prime target for antiviral inhibitors.
T411 205-428 Sentence denotes Remdesivir, an adenosine triphosphate analog, inhibits RdRp by binding to RNA strands and preventing additional nucleotides from being added, thereby terminating viral RNA transcription (Figure 6 A) (Agostini et al., 2018).
T412 429-586 Sentence denotes Remdesivir has been previously shown to be effective against MERS-CoV and SARS-CoV-1 infections in animal models (Sheahan et al., 2017, de Wit et al., 2020).
T413 587-732 Sentence denotes Similarly, a study investigated the efficacy of remdesivir treatments on 12 rhesus macaques with SARS-CoV-2 infections (Williamson et al., 2020).
T414 733-863 Sentence denotes Macaques treated with remdesivir showed a reduction in lung viral loads and pneumonia symptoms but no reduction in virus shedding.
T415 864-994 Sentence denotes This study does provide evidence that if administered early enough, remdesivir may be effective at treating SARS-CoV-2 infections.
T416 995-1099 Sentence denotes Figure 6 Available Therapeutic Options to Manage COVID-19 Immunopathology and to Deter Viral Propagation
T417 1100-1314 Sentence denotes (A) Rdrp inhibitors (remdesivir, favipiravir), protease inhibitors (lopinavir/ritonavir), and antifusion inhibitors (arbidol) are currently being investigated in their efficacy in controlling SARS-CoV-2 infections.
T418 1315-1422 Sentence denotes (B) CQ and HCQ increase the pH within lysosomes, impairing viral transit through the endolysosomal pathway.
T419 1423-1571 Sentence denotes Reduced proteolytic function within lysosomes augments antigen processing for presentation on MHC complexes and increases CTLA4 expression on Tregs.
T420 1572-1707 Sentence denotes (C) Antagonism of IL-6 signaling pathway and of other cytokine-/chemokine-associated targets has been proposed to control COVID-19 CRS.
T421 1708-1828 Sentence denotes These include secreted factors like GM-CSF that contribute to the recruitment of inflammatory monocytes and macrophages.
T422 1829-2045 Sentence denotes (D) Several potential sources of SARS-CoV-2 neutralizing antibodies are currently under investigation, including monoclonal antibodies, polyclonal antibodies, and convalescent plasma from recovered COVID-19 patients.
T423 2046-2181 Sentence denotes GM-CSF, granulocyte-macrophage colony-stimulating factor; CQ, chloroquine; HCQ, hydroxychloroquine; RdRp, RNA-dependent RNA polymerase.