LitCovid-sentences  

PMC:7200337 / 7179-9094 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T42 0-316 Sentence denotes CoV-mediated antagonism of innate immunity begins with evasion of PRR sensing. ssRNA viruses, like CoVs, form dsRNA intermediates during their replication, which can be detected by TLR3 in the endosome and RIG-I, MDA5, and PKR in the cytosol. ssRNA may also be detected by TLR7 or TLR8 and potentially RIG-I and PKR.
T43 317-550 Sentence denotes CoVs are known to avoid PRR activation by either avoiding recognition altogether or antagonizing PRR action (Bouvet et al., 2010, Chen et al., 2009, Deng et al., 2017, Hackbart et al., 2020, Ivanov et al., 2004, Knoops et al., 2008).
T44 551-692 Sentence denotes To evade PRRs, dsRNA is first shielded by membrane-bound compartments that form during viral replication of SARS-CoV-1 (Knoops et al., 2008).
T45 693-982 Sentence denotes In addition, viral RNA is guanosine-capped and methylated at the 5′ end by CoVs non-structural proteins (NSPs) 10, 13, 14, and 16 (Bouvet et al., 2010, Chen et al., 2009, Ivanov et al., 2004), thereby resembling host mRNA to promote translation, prevent degradation, and evade RLR sensing.
T46 983-1184 Sentence denotes Finally, CoVs also encode an endoribonuclease, NSP15, that cleaves 5′ polyuridines formed during viral replication, which would otherwise be detected by MDA5 (Deng et al., 2017, Hackbart et al., 2020).
T47 1185-1254 Sentence denotes CoVs have evolved additional strategies to impede activation of PRRs.
T48 1255-1330 Sentence denotes SARS-CoV-1 N-protein prevents TRIM25 activation of RIG-I (Hu et al., 2017).
T49 1331-1529 Sentence denotes Likewise, MERS-CoV NS4a, which itself binds dsRNA, impedes PKR activation (Comar et al., 2019, Rabouw et al., 2016) and inhibits PACT, an activator of RLRs (Niemeyer et al., 2013, Siu et al., 2014).
T50 1530-1631 Sentence denotes Additionally, MERS-CoV NS4b antagonizes RNaseL, another activator of RLRs (Thornbrough et al., 2016).
T51 1632-1671 Sentence denotes The role of other PRRs remains unclear.
T52 1672-1826 Sentence denotes For example, SARS-CoV-1 papain-like protease (PLP) antagonizes STING, suggesting that self-DNA may also represent an important trigger (Sun et al., 2012).
T53 1827-1915 Sentence denotes The extent to which SARS-CoV-2 homologs overlap in these functions is currently unknown.