LitCovid-sentences  

PMC:7200337 / 58494-64388 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T321 0-82 Sentence denotes Table 1 Routine Blood and Immunological Prognostic Biomarkers in COVID-19 Patients
T322 83-100 Sentence denotes Biomarker Purpose
T323 101-532 Sentence denotes Routine Bloodwork Lymphocyte count Predicted the disease severity and the outcomes of hospitalized patients (Tan et al., 2020a).Prognostic value was confirmed in numerous studies (Huang et al., 2020d, Liu et al., 2020b, Song et al., 2020, Wang et al., 2020f, Wynants et al., 2020, Yan et al., 2020b, Yang et al., 2020b, Zhang et al., 2020c, Zhao et al., 2020d).Decreased continuously in non-surviving patients (Wang et al., 2020b).
T324 533-806 Sentence denotes N/L Patients with N/L ≥3.13 were reported to be more likely to develop severe illness and to require ICU admission (Liu et al., 2020c).N/L on admission was a risk factor for short-term progression of patients with moderate pneumonia to severe pneumonia (Feng et al., 2020).
T325 807-936 Sentence denotes Confirmed to be of prognostic value in COVID-19 in several studies (Song et al., 2020, Wynants et al., 2020, Zhou et al., 2020d).
T326 937-1013 Sentence denotes CRP Proposed as an early biomarker of disease progression (Ji et al., 2020).
T327 1014-1136 Sentence denotes Even in early stages, CRP levels were positively correlated with lung lesions and reflected disease severity (Wang, 2020).
T328 1137-1287 Sentence denotes Confirmed in numerous studies (Fu et al., 2020, Huang et al., 2020d, Wynants et al., 2020, Yan et al., 2020b, Zhao et al., 2020d, Zhou et al., 2020b).
T329 1288-1372 Sentence denotes Predicted the risk of acute myocardial injury (Liu et al., 2020g, Xu et al., 2020a).
T330 1373-1441 Sentence denotes LDH Higher in severe cases than in mild cases (Xiang et al., 2020a).
T331 1442-1578 Sentence denotes Widely proposed to have prognostic value in COVID-19 (Huang et al., 2020d, Wynants et al., 2020, Yan et al., 2020b, Zhao et al., 2020d).
T332 1579-1689 Sentence denotes D-dimer (and coagulation parameters) Predicted severity independently of other variables (Zhou et al., 2020d).
T333 1690-1797 Sentence denotes Elevated levels and disseminated intravascular coagulation are found in non-survivors (Wang et al., 2020b).
T334 1798-1871 Sentence denotes Identified patients at risk for acute cardiac injury (Liu et al., 2020g).
T335 1872-2075 Sentence denotes Other coagulation parameters, such as fibrin degradation product levels, longer prothrombin time, and activated partial thromboplastin time, were also associated with poor prognosis (Tang et al., 2020a).
T336 2076-2222 Sentence denotes SAA SAA was proposed to be used as an auxiliary index for diagnosis as it was elevated in 80% of the patients in a small cohort (Ji et al., 2020).
T337 2223-2392 Sentence denotes NT-proBNP (N-terminal pro B type natriuretic peptide) NT-proBNP was an independent risk factor of in-hospital death in patients with severe COVID-19 (Gao et al., 2020b).
T338 2393-2494 Sentence denotes Platelet count High platelet-to-lymphocyte ratio was associated with worse outcome (Qu et al., 2020).
T339 2495-2635 Sentence denotes Thrombocytopenia was associated with poor outcome and with incidence of myocardial injury in COVID-19 (Liu et al., 2020h, Shi et al., 2020).
T340 2636-2778 Sentence denotes Immunological CD4+, CD8+, and NK cell counts Lower CD4+, CD8+, and NK cells in PBMCs correlated with severity of COVID-19 (Nie et al., 2020b).
T341 2779-2850 Sentence denotes Validated by several studies (Wang et al., 2020f, Zheng et al., 2020b).
T342 2851-3042 Sentence denotes PD-1 and Tim-3 expression on T cells Increasing PD-1 and Tim-3 expression on T cells could be detected as patients progressed from prodromal to overtly symptomatic stages (Diao et al., 2020).
T343 3043-3194 Sentence denotes Expression was higher in infected patients versus healthy controls and in ICU versus non-ICU patients in both CD4 and CD8 T cells (Zhou et al., 2020b).
T344 3195-3519 Sentence denotes phenotypic changes in peripheral blood monocytes The presence of a distinct population of monocytes with high forward scatter (CD11b+, CD14+, CD16+, CD68+, CD80+, CD163+, and CD206+, which secrete IL-6, IL-10, and TNF-α) was identified in patients requiring prolonged hospitalization and ICU admission (Zhang et al., 2020c).
T345 3520-3597 Sentence denotes CD14+CD16+IL-6+ monocytes are increased in ICU patients (Zhou et al., 2020b).
T346 3598-3814 Sentence denotes IP-10, MCP-3, and IL-1ra IP-10, MCP-3, and IL-1ra were, among 48 examined cytokines, the only ones that closely associated with disease severity and outcome of COVID-19 in a study by Yang et al. (Yang et al., 2020b).
T347 3815-4008 Sentence denotes IL-6 Associated with disease severity (hospitalization and ICU admission) and poor prognosis (Chen et al., 2020g, Huang et al., 2020b, Liu et al., 2020b, Liu et al., 2020f, Wang et al., 2020b).
T348 4009-4102 Sentence denotes Increased levels were associated with higher risk of respiratory failure (Yao et al., 2020b).
T349 4103-4243 Sentence denotes IL-8 Positively correlated with disease severity (Chen et al., 2020e, Gong et al., 2020), with severe cases showing the highest IL-8 levels.
T350 4244-4461 Sentence denotes IL-10 Increased in severe or critical patients as compared to mild patients (Gong et al., 2020, Zhou et al., 2020d) without a statistically significant difference between severe and critical cases (Gong et al., 2020).
T351 4462-4655 Sentence denotes IL-2R Associated with disease severity in a study that, among other cytokines, also associated ferroprotein levels, PCT levels, and eosinophil counts with COVID-19 severity (Gong et al., 2020).
T352 4656-4835 Sentence denotes IL-1β CD14+IL-1β+ monocytes are abundant in early-recovery patients as shown in a single-cell RNA-seq analysis and thought to be associated with cytokine storm (Wen et al., 2020).
T353 4836-4970 Sentence denotes IL-1β did not correlate with disease severity in a cross-sectional study with mild, severe, and critical patients (Gong et al., 2020).
T354 4971-5115 Sentence denotes IL-4 IL-4 was associated with impaired lung lesions (Fu et al., 2020), but some reports point to a potential mediator effect (Wen et al., 2020).
T355 5116-5347 Sentence denotes IL-18 In modeling immune cell interaction between DCs and B cells in late recovery COVID-19 patients, IL-18 was found to be important in B cell production of antibodies, which suggests its importance in recovery (Wen et al., 2020).
T356 5348-5420 Sentence denotes GM-CSF GM-CSF+IFN-γ+ T cells are higher in ICU than in non-ICU patients.
T357 5421-5534 Sentence denotes CD14+CD16+GM-CSF+ monocytes are higher in COVID-19 patients as compared to healthy controls (Zhou et al., 2020b).
T358 5535-5635 Sentence denotes IL-2 and IFN-γ IL-2 and IFN-γ levels were shown to be increased in severe cases (Liu et al., 2020b).
T359 5636-5781 Sentence denotes anti-SARS-CoV-2 antibody levels Prolonged SARS-CoV-2 IgM positivity could be utilized as a predictive factor for poor recovery (Fu et al., 2020).
T360 5782-5894 Sentence denotes Higher anti-SARS-CoV-2 IgG levels and higher N/L were more commonly found in severe cases (Zhang et al., 2020a).