| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T217 |
0-113 |
Sentence |
denotes |
Currently, little is known about specific phenotypical and/or functional T cell changes associated with COVID-19. |
| T218 |
114-456 |
Sentence |
denotes |
In the majority of preprints and peer-reviewed studies, there are reports of increased presence of activated T cells (Figure 3) characterized by expression of HLA-DR, CD38, CD69, CD25, CD44, and Ki-67 (Braun et al., 2020, Ni et al., 2020, Guo et al., 2020, Liao et al., 2020, Thevarajan et al., 2020, Yang et al., 2020a, Zheng et al., 2020a). |
| T219 |
457-727 |
Sentence |
denotes |
Generally, independent of COVID-19 disease severity, CD8 T cells seem to be more activated than CD4 T cells (Qin et al., 2020, Thevarajan et al., 2020, Yang et al., 2020a), a finding that echoes stronger CD8 than CD4 T cell responses during SARS-CoV-1 (Li et al., 2008). |
| T220 |
728-903 |
Sentence |
denotes |
Furthermore, in a case study of 10 COVID-19 patients, Diao et al. showed that levels of PD-1 increased from prodromal to symptomatic stages of the disease (Diao et al., 2020). |
| T221 |
904-1124 |
Sentence |
denotes |
PD-1 expression is commonly associated with T cell exhaustion, but it is important to emphasize that PD-1 is primarily induced by TCR signaling; it is thus also expressed by activated effector T cells (Ahn et al., 2018). |
