| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T173 |
0-124 |
Sentence |
denotes |
A decrease in peripheral blood T cells associated with disease severity and inflammation is now well documented in COVID-19. |
| T174 |
125-409 |
Sentence |
denotes |
Several studies report increased numbers of activated CD4 and CD8 T cells, which display a trend toward an exhausted phenotype in persistent COVID-19, based on continuous and upregulated expression of inhibitory markers as well as potential reduced polyfunctionality and cytotoxicity. |
| T175 |
410-513 |
Sentence |
denotes |
In severe disease, production of specific inflammatory cytokines by CD4 T cells has also been reported. |
| T176 |
514-671 |
Sentence |
denotes |
This working model needs to be confirmed and expanded on in future studies to assess virus-specific T cell responses both in peripheral blood and in tissues. |
| T177 |
672-834 |
Sentence |
denotes |
In addition, larger and more defined patient cohorts with longitudinal data are required to define the relationship between disease severity and T cell phenotype. |
