| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T172 |
50-110 |
Sentence |
denotes |
Changes in Peripheral Blood T Cell Frequencies and Phenotype |
| T173 |
111-235 |
Sentence |
denotes |
A decrease in peripheral blood T cells associated with disease severity and inflammation is now well documented in COVID-19. |
| T174 |
236-520 |
Sentence |
denotes |
Several studies report increased numbers of activated CD4 and CD8 T cells, which display a trend toward an exhausted phenotype in persistent COVID-19, based on continuous and upregulated expression of inhibitory markers as well as potential reduced polyfunctionality and cytotoxicity. |
| T175 |
521-624 |
Sentence |
denotes |
In severe disease, production of specific inflammatory cytokines by CD4 T cells has also been reported. |
| T176 |
625-782 |
Sentence |
denotes |
This working model needs to be confirmed and expanded on in future studies to assess virus-specific T cell responses both in peripheral blood and in tissues. |
| T177 |
783-945 |
Sentence |
denotes |
In addition, larger and more defined patient cohorts with longitudinal data are required to define the relationship between disease severity and T cell phenotype. |
| T178 |
946-1112 |
Sentence |
denotes |
IL, interleukin; IFN, interferon; TNF, tumor necrosis factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; GzmA/B, granzyme A/granzyme B; Prf1, perforin. |
