| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T129 |
0-49 |
Sentence |
denotes |
NK Cell Activation Pathways in Antiviral Immunity |
| T130 |
50-136 |
Sentence |
denotes |
NK cells express inhibitory and activating receptors that regulate their cytotoxicity. |
| T131 |
137-451 |
Sentence |
denotes |
They are therefore able to induce the lysis of virus-infected cells that upregulate virus-derived proteins, as well as stress-inducible ligands, which are then recognized by NK-cell-activating receptors, such as NKp46 (Cerwenka and Lanier, 2001, Draghi et al., 2007, Duev-Cohen et al., 2016, Glasner et al., 2012). |
| T132 |
452-648 |
Sentence |
denotes |
Future studies should investigate the expression of NK receptor ligands on SARS-CoV-2-infected cells in order to better understand the mechanisms underlying NK cell activation in COVID-19 disease. |
| T133 |
649-956 |
Sentence |
denotes |
Further, secretion of IgG1 and IgG3 antibodies during SARS-CoV-2 infection (Amanat et al., 2020) may induce CD56dim CD16+ NK cell activation through Fc receptor recognition of antibodies either bound to surface antigens expressed on infected cells or to extracellular virions as immune complexes (Figure 2). |
| T134 |
957-1169 |
Sentence |
denotes |
This interaction might trigger both cytokine production by NK cells and lysis of infected cells through antibody-mediated cellular cytotoxicity (ADCC), as shown in influenza infection (Von Holle and Moody, 2019). |
| T135 |
1170-1409 |
Sentence |
denotes |
Emerging data highlight the capacity for NK-mediated ADCC in response to naturally isolated SARS-CoV-1 anti-S IgG that crossreacts with SARS-CoV-2 S glycoprotein when transfected into Chinese hamster ovary (CHO) cells (Pinto et al., 2020). |
| T136 |
1410-1574 |
Sentence |
denotes |
These findings suggest that triggering NK cell activation may not only contribute to the resolution of infection, but also contribute to the cytokine storm in ARDS. |
