| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T97 |
85-178 |
Sentence |
denotes |
Based on data from preliminary COVID-19 studies and earlier studies in related coronaviruses. |
| T98 |
179-407 |
Sentence |
denotes |
IL-6, IL-1β, and IFN-I/III from infected pulmonary epithelia can induce inflammatory programs in resident (alternate) macrophages while recruiting inflammatory monocytes, as well as granulocytes and lymphocytes from circulation. |
| T99 |
408-500 |
Sentence |
denotes |
Sustained IL-6 and TNF-ɑ by incoming monocytes can drive several hyperinflammation cascades. |
| T100 |
501-623 |
Sentence |
denotes |
Inflammatory monocyte-derived macrophages can amplify dysfunctional responses in various ways (listed in top-left corner). |
| T101 |
624-761 |
Sentence |
denotes |
The systemic CRS- and sHLH-like inflammatory response can induce neutrophilic NETosis and microthrombosis, aggravating COVID-19 severity. |
| T102 |
762-858 |
Sentence |
denotes |
Other myeloid cells, such as pDCs, are purported to have an IFN-dependent role in viral control. |
| T103 |
859-922 |
Sentence |
denotes |
Monocyte-derived CXCL9/10/11 might recruit NK cells from blood. |
| T104 |
923-1083 |
Sentence |
denotes |
Preliminary data suggest that the antiviral function of these NK cells might be regulated through crosstalk with SARS-infected cells and inflammatory monocytes. |
| T105 |
1084-1131 |
Sentence |
denotes |
Dashed lines indicate pathways to be confirmed. |
| T106 |
1132-1394 |
Sentence |
denotes |
Arg1, arginase 1; iNOS, inducible-nitric oxide synthase; Inflamm., inflammatory; Mono., monocytes; Macs, macrophages; Eosino, eosinophils; Neutro, neutrophils; NETosis, neutrophil extracellular trap cell death; SHLH, secondary hemophagocytic lymphohistiocytosis. |
