| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T80 |
0-36 |
Sentence |
denotes |
Myeloid Characterization in COVID-19 |
| T81 |
37-396 |
Sentence |
denotes |
Flow cytometric analyses of peripheral blood mononuclear cells (PBMCs) from symptomatic COVID-19 patients have shown a significant influx of granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing, activated CD4+ T cells and CD14+HLA-DRlo inflammatory monocytes (IMs) (Giamarellos-Bourboulis et al., 2020, Zhang et al., 2020c, Zhou et al., 2020b). |
| T82 |
397-841 |
Sentence |
denotes |
This matches single-cell transcriptomic (scRNA-seq) data demonstrating CD14+IL-1β+ monocytic expansion (Guo et al., 2020, Wen et al., 2020), interferon-mitogen-activated protein kinase (MAPK)-driven adaptive immune responses (Huang et al., 2020c), and IL-1β-associated inflammasome signatures (Ong et al., 2020) in peripheral blood of COVID-19 patients, although systemic levels of IL-1β detected are conspicuously low (Del Valle et al., 2020). |
| T83 |
842-1183 |
Sentence |
denotes |
Importantly, these immune signatures track with progression of clinical disease. scRNA-seq studies performed on pulmonary tissues of patients with severe COVID-19 disease have revealed an expansion of IMs and Ficolin-1+ monocyte-derived macrophages at the expense of tissue-resident reparative alveolar macrophages (AMs) (Liao et al., 2020). |
| T84 |
1184-1357 |
Sentence |
denotes |
The aforementioned study also observed signatures of IFN signaling and monocyte recruitment that likely contribute to the rapid decline in alveolar patency and promote ARDS. |
| T85 |
1358-1603 |
Sentence |
denotes |
Although most of the clinical focus has been on pulmonary damage and mononuclear phagocyte (MNP) dysfunction therein, it is increasingly clear that COVID-19 likely presents systemic challenges in other organ sites, such as the ileum and kidneys. |
| T86 |
1604-1730 |
Sentence |
denotes |
Understanding the role of non-pulmonary myeloid cells in tissue-specific pathology associated with COVID-19 will be important. |
