Id |
Subject |
Object |
Predicate |
Lexical cue |
T677 |
0-123 |
Sentence |
denotes |
However, in many other ways, immune responses to SARS-CoV-2 are distinct from those seen with other coronavirus infections. |
T678 |
124-464 |
Sentence |
denotes |
The emerging epidemiological observation that significant proportions of individuals are asymptomatic despite infection not only reflects our current understanding that SARS-CoV-2 has a longer incubation period and higher rate of transmission than other coronaviruses, but also speaks to significant differences in the host immune response. |
T679 |
465-663 |
Sentence |
denotes |
Therefore, it is imperative that immune responses against SARS-CoV-2 and mechanisms of hyperinflammation-driven pathology are further elucidated to better define therapeutic strategies for COVID-19. |
T680 |
664-1004 |
Sentence |
denotes |
Here, we reviewed the recent literature and highlighted hypotheses that interrogate mechanisms for viral escape from innate sensing, for hyperinflammation associated with CRS and inflammatory myeloid subpopulations, for lymphopenia marked by T cell and NK cell dysfunction, and for correlates of protection and their duration, among others. |
T681 |
1005-1212 |
Sentence |
denotes |
Still, additional studies are needed to address how these immune differences across patients or between different types of coronavirus infections dictate who succumbs to disease and who remains asymptomatic. |
T682 |
1213-1357 |
Sentence |
denotes |
Existing studies of SARS-CoV-1 and MERS-CoV and ongoing studies of SARS-CoV-2 will likely provide a robust framework to fulfill that unmet need. |