PMC:7200337 / 114022-115379 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T677 0-123 Sentence denotes However, in many other ways, immune responses to SARS-CoV-2 are distinct from those seen with other coronavirus infections.
T678 124-464 Sentence denotes The emerging epidemiological observation that significant proportions of individuals are asymptomatic despite infection not only reflects our current understanding that SARS-CoV-2 has a longer incubation period and higher rate of transmission than other coronaviruses, but also speaks to significant differences in the host immune response.
T679 465-663 Sentence denotes Therefore, it is imperative that immune responses against SARS-CoV-2 and mechanisms of hyperinflammation-driven pathology are further elucidated to better define therapeutic strategies for COVID-19.
T680 664-1004 Sentence denotes Here, we reviewed the recent literature and highlighted hypotheses that interrogate mechanisms for viral escape from innate sensing, for hyperinflammation associated with CRS and inflammatory myeloid subpopulations, for lymphopenia marked by T cell and NK cell dysfunction, and for correlates of protection and their duration, among others.
T681 1005-1212 Sentence denotes Still, additional studies are needed to address how these immune differences across patients or between different types of coronavirus infections dictate who succumbs to disease and who remains asymptomatic.
T682 1213-1357 Sentence denotes Existing studies of SARS-CoV-1 and MERS-CoV and ongoing studies of SARS-CoV-2 will likely provide a robust framework to fulfill that unmet need.