LitCovid-sentences  

PMC:7200337 / 113372-115379 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T672 0-18 Sentence denotes Concluding Remarks
T673 19-236 Sentence denotes The rapid spread of SARS-CoV-2 and the unprecedented nature of COVID-19 has demanded an urgency in both basic science and clinical research, and the scientific community has met that call with remarkable productivity.
T674 237-384 Sentence denotes Within months, there has been a significant generation of scientific knowledge that has shed some light on the immunology of SARS-CoV-2 infections.
T675 385-506 Sentence denotes Studies of past coronavirus outbreaks involving SARS-CoV-1 and MERS-CoV have provided a foundation for our understanding.
T676 507-649 Sentence denotes The pathology of severe cases of COVID-19 does indeed resemble certain immunopathologies seen in SARS-CoV-1 and MERS-CoV infections, like CRS.
T677 650-773 Sentence denotes However, in many other ways, immune responses to SARS-CoV-2 are distinct from those seen with other coronavirus infections.
T678 774-1114 Sentence denotes The emerging epidemiological observation that significant proportions of individuals are asymptomatic despite infection not only reflects our current understanding that SARS-CoV-2 has a longer incubation period and higher rate of transmission than other coronaviruses, but also speaks to significant differences in the host immune response.
T679 1115-1313 Sentence denotes Therefore, it is imperative that immune responses against SARS-CoV-2 and mechanisms of hyperinflammation-driven pathology are further elucidated to better define therapeutic strategies for COVID-19.
T680 1314-1654 Sentence denotes Here, we reviewed the recent literature and highlighted hypotheses that interrogate mechanisms for viral escape from innate sensing, for hyperinflammation associated with CRS and inflammatory myeloid subpopulations, for lymphopenia marked by T cell and NK cell dysfunction, and for correlates of protection and their duration, among others.
T681 1655-1862 Sentence denotes Still, additional studies are needed to address how these immune differences across patients or between different types of coronavirus infections dictate who succumbs to disease and who remains asymptomatic.
T682 1863-2007 Sentence denotes Existing studies of SARS-CoV-1 and MERS-CoV and ongoing studies of SARS-CoV-2 will likely provide a robust framework to fulfill that unmet need.