LitCovid-sentences  

PMC:7200337 / 100788-103276 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T590 0-268 Sentence denotes Some studies and case reports on CP therapy for COVID-19 have evaluated the safety and the potential effectiveness of CP therapy in patients with severe disease (Ahn et al., 2020, Duan et al., 2020, Pei et al., 2020, Shen et al., 2020, Zhang et al., 2020b) (Table 4 ).
T591 269-431 Sentence denotes These studies were neither controlled nor randomized, but they suggest that CP therapy is safe and can have a beneficial effect on the clinical course of disease.
T592 432-531 Sentence denotes Further controlled trials are needed to determine the optimal timing and indication for CP therapy.
T593 532-711 Sentence denotes CP therapy has also been proposed for prophylactic use in at-risk individuals, such as those with underlying health conditions or health care workers exposed to COVID-19 patients.
T594 712-794 Sentence denotes The FDA has approved the use of CP to treat critically ill patients (Tanne, 2020).
T595 795-1063 Sentence denotes Determining when to administer the CP is also of great importance, as a study in SARS-CoV-1 patients showed that CP was much more efficient when given to patients before day 14 day of illness (Cheng et al., 2005b), as previously shown in influenza (Luke et al., 2006).
T596 1064-1161 Sentence denotes This study also showed that CP therapy was more efficient in PCR-positive, seronegative patients.
T597 1162-1258 Sentence denotes The amount of plasma and number of transfusions needed requires further investigation (Table 4).
T598 1259-1335 Sentence denotes Table 4 Clinical Studies of Convalescent Plasma Therapy in COVID-19 Patients
T599 1336-1397 Sentence denotes Patient Characteristics Start of CP Therapy Results Reference
T600 1398-1553 Sentence denotes 5 severe patients (30–70 yo) between 10 and 22 days after hospital admission body temperature normalized within 3 days in 4 of 5 patients Shen et al., 2020
T601 1554-1574 Sentence denotes clinical improvement
T602 1575-1636 Sentence denotes viral loads became negative within 12 days of the transfusion
T603 1637-1657 Sentence denotes nAb titers increased
T604 1658-1765 Sentence denotes 10 severe patients (34–78 yo) median 16.5 dpo disappearance of clinical symptoms after 3d Duan et al., 2020
T605 1766-1783 Sentence denotes chest CT improved
T606 1784-1848 Sentence denotes elevation of lymphocyte counts in patients with lymphocytopenia.
T607 1849-1881 Sentence denotes increase in SaO2 in all patients
T608 1882-1928 Sentence denotes resolution of SARS-CoV-2 viremia in 7 patients
T609 1929-1983 Sentence denotes increase in neutralizing antibody titers in 5 patients
T610 1984-2130 Sentence denotes 4 critical patients (31–73 yo) at degradation of symptoms,between 11 and 19 days after hospital admission clinical improvement Zhang et al., 2020b
T611 2131-2149 Sentence denotes reduced viral load
T612 2150-2167 Sentence denotes chest CT improved
T613 2168-2280 Sentence denotes 1 moderate patient, 2 critical patients 12 dpo, 27 dpo viral detection negative 4 days after CP Pei et al., 2020
T614 2281-2315 Sentence denotes clinical improvement of 2 patients
T615 2316-2402 Sentence denotes 2 severe patients (67 and 71 yo) 7 dpo or 22 dpo clinical improvement Ahn et al., 2020
T616 2403-2421 Sentence denotes reduced viral load
T617 2422-2439 Sentence denotes chest CT improved
T618 2440-2488 Sentence denotes yo, years old; dpo, days post onset of symptoms.