| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T393 |
0-258 |
Sentence |
denotes |
Pending results of RCT, the use of hydroxychloroquine may be considered for treating worsening patients with COVID-19 only if no important drug interactions can be anticipated and with close monitoring of hepatic function, renal function and QT prolongation. |
| T394 |
259-467 |
Sentence |
denotes |
This is based on its activity in vitro against SARS-CoV-2 (although weak) and on the availability of low-level clinical evidence of anticipation of virus clearance from a small controlled nonrandomized study. |
| T395 |
468-640 |
Sentence |
denotes |
However, it should also be kept in mind that the study was highly susceptible to bias and there are still no data regarding hard clinical endpoints such as crude mortality. |
| T396 |
641-765 |
Sentence |
denotes |
For these reasons, hydroxychloroquine should be preferentially administered within the framework of investigational studies. |
| T397 |
766-875 |
Sentence |
denotes |
When this is unfeasible, off-label use may be considered according to local protocols and consent procedures. |
| T398 |
876-1072 |
Sentence |
denotes |
In view of the absence of evidence, we are currently unable to support the use of hydroxychloroquine in asymptomatic or mildly symptomatic nonhospitalized patients outside investigational studies. |
| T399 |
1073-1110 |
Sentence |
denotes |
The same applies to prophylactic use. |
