Id |
Subject |
Object |
Predicate |
Lexical cue |
T97 |
91-132 |
Sentence |
denotes |
Open-label RCT (NCT04307693, recruiting). |
T98 |
133-192 |
Sentence |
denotes |
Primary endpoint: virus load at day 3, 5, 7, 10, 14 and 18. |
T99 |
193-296 |
Sentence |
denotes |
• Comparison of ASC09/ritonavir vs. lopinavir/ritonavir in patients with confirmed COVID-19 pneumoniae. |
T100 |
297-346 |
Sentence |
denotes |
Open-label RCT (NCT04261907, not yet recruiting). |
T101 |
347-516 |
Sentence |
denotes |
Primary endpoint: adverse outcome at day 14 (composite of Spo 2 ≤ 93% without oxygen supplementation, PaO2/FiO2 ≤ 300 mm Hg or respiratory rate ≥ 30 breaths per minute). |
T102 |
517-619 |
Sentence |
denotes |
• Comparison of lopinavir/ritonavir vs. lopinavir/ritonavir plus umifenovir in patients with COVID-19. |
T103 |
620-661 |
Sentence |
denotes |
Open-label RCT (NCT04252885, recruiting). |
T104 |
662-738 |
Sentence |
denotes |
Primary endpoint: rate of virus inhibition at day 0, 2, 4, 7, 10, 14 and 21. |
T105 |
739-864 |
Sentence |
denotes |
• Comparison of lopinavir/ritonavir vs. lopinavir/ritonavir plus ribavirin plus interferon beta 1b in patients with COVID-19. |
T106 |
865-906 |
Sentence |
denotes |
Open-label RCT (NCT04276688, recruiting). |
T107 |
907-989 |
Sentence |
denotes |
Primary endpoint: time to negative nasopharyngeal swab RT-PCR (follow-up 30 days). |
T108 |
990-1133 |
Sentence |
denotes |
• Comparison of only supportive treatment vs. lopinavir/ritonavir vs. oseltamivir vs. umifenovir in patients with confirmed COVID-19 pneumonia. |
T109 |
1134-1175 |
Sentence |
denotes |
Open-label RCT (NCT04255017, recruiting). |
T110 |
1176-1451 |
Sentence |
denotes |
Primary endpoints: (a) rate of disease remission (mild disease: fever, cough and other symptoms relieved with improved lung CT; severe disease: fever, cough and other symptoms relieved with improved lung CT, Spo 2 > 93% or Pao 2/Fio 2 > 300 mm Hg); (b) time to lung recovery. |
T111 |
1452-1564 |
Sentence |
denotes |
• Comparison of chemoprophylaxis with lopinavir/ritonavir vs. placebo in healthcare workers exposed to COVID-19. |
T112 |
1565-1616 |
Sentence |
denotes |
Double-blind RCT (NCT04328285, not yet recruiting). |
T113 |
1617-1711 |
Sentence |
denotes |
Primary endpoint: occurrence of a symptomatic or asymptomatic COVID-19 (follow-up 2.5 months). |
T114 |
1712-1828 |
Sentence |
denotes |
• Comparison of carrimycin vs. lopinavir/ritonavir or umifenovir or chloroquine in patients with COVID-19 pneumonia. |
T115 |
1829-1878 |
Sentence |
denotes |
Open-label RCT (NCT04286503, not yet recruiting). |
T116 |
1879-2061 |
Sentence |
denotes |
Primary endpoints: (a) fever to normal time (follow-up 30 days); (b) pulmonary inflammation resolution time (follow-up 30 days); (c) negative conversion of throat swab RT-PCR at EOT. |
T117 |
2062-2244 |
Sentence |
denotes |
• Comparison of lopinavir/ritonavir vs. lopinavir/ritonavir plus xiyanping (injectable component derived from a plant used in traditional Chinese medicine) in patients with COVID-19. |
T118 |
2245-2294 |
Sentence |
denotes |
Open-label RCT (NCT04295551, not yet recruiting). |
T119 |
2295-2356 |
Sentence |
denotes |
Primary endpoint: clinical recovery time (follow-up 28 days). |
T120 |
2357-2526 |
Sentence |
denotes |
• Comparison of lopinavir/ritonavir plus inhaled interferon alfa vs. lopinavir/ritonavir plus inhaled interferon alfa plus xiyanping injection in patients with COVID-19. |
T121 |
2527-2576 |
Sentence |
denotes |
Open-label RCT (NCT04275388, not yet recruiting). |
T122 |
2577-2638 |
Sentence |
denotes |
Primary endpoint: clinical recovery time (follow-up 14 days). |
T123 |
2639-2818 |
Sentence |
denotes |
• Comparison of lopinavir/ritonavir plus inhaled interferon alfa vs. lopinavir/ritonavir plus inhaled interferon alfa plus traditional Chinese medicines in patients with COVID-19. |
T124 |
2819-2860 |
Sentence |
denotes |
Open-label RCT (NCT04251871, recruiting). |
T125 |
2861-2938 |
Sentence |
denotes |
Primary endpoint: time to complete remission of symptoms (follow-up 28 days). |
T126 |
2939-3154 |
Sentence |
denotes |
• Comparison of lopinavir/ritonavir plus hydroxychloroquine vs. lopinavir/ritonavir plus hydroxychloroquine plus levamisole pill plus budesonide plus formoterol inhaler in patients with nonsevere COVID-19 pneumonia. |
T127 |
3155-3208 |
Sentence |
denotes |
Partly blinded RCT (NCT04331470, not yet recruiting). |
T128 |
3209-3290 |
Sentence |
denotes |
Primary endpoint: (a) clear CT scan at 3–7 days; (b) negative RT-PCR at 3–7 days. |
T129 |
3291-3402 |
Sentence |
denotes |
• Comparison of lopinavir/ritonavir vs. hydroxychloroquine vs. losartan vs. placebos in patients with COVID-19. |
T130 |
3403-3464 |
Sentence |
denotes |
Double-blind, adaptive RCT (NCT04328012, not yet recruiting). |
T131 |
3465-3541 |
Sentence |
denotes |
Primary endpoint: NIAID COVID-19 ordinal severity scale (follow-up 60 days). |
T132 |
3542-3711 |
Sentence |
denotes |
• Comparison of lopinavir/ritonavir vs. hydroxychloroquine vs. lopinavir/ritonavir plus interferon beta 1a vs. remdesivir vs. standard of care in patients with COVID-19. |
T133 |
3712-3765 |
Sentence |
denotes |
Double-blind, adaptive RCT (NCT04315948, recruiting). |
T134 |
3766-3837 |
Sentence |
denotes |
Primary endpoint: severity rating on a 7-point ordinal scale at day 15. |
T135 |
3838-4137 |
Sentence |
denotes |
• Comparison of lopinavir/ritonavir or umifenovir or chloroquine or hydroxychloroquine or oseltamivir (with or without azithromycin) vs. natural honey plus lopinavir/ritonavir or umifenovir or chloroquine or hydroxychloroquine or oseltamivir (with or without azithromycin) in patients with COVID-19. |
T136 |
4138-4189 |
Sentence |
denotes |
Single-blind RCT (NCT04323345, not yet recruiting). |
T137 |
4190-4383 |
Sentence |
denotes |
Primary endpoints: (a) positive to negative swabs at day 14; (b) fever to normal temperature in days (follow-up 14 days); (c) resolution of lung inflammation in CT or X-ray (follow-up 30 days). |
T138 |
4384-4521 |
Sentence |
denotes |
• Comparison of colchicine (with or without lopinavir/ritonavir) vs. local standard of care in patients with moderate to severe COVID-19. |
T139 |
4522-4571 |
Sentence |
denotes |
Open-label RCT (NCT04328480, not yet recruiting). |
T140 |
4572-4630 |
Sentence |
denotes |
Primary endpoint: all-cause mortality (follow-up 30 days). |
T141 |
4631-5035 |
Sentence |
denotes |
• Comparison of oseltamivir plus chloroquine vs. oseltamivir plus lopinavir/ritonavir in patients with mild COVID-19 and of lopinavir/ritonavir plus oseltamivir vs. darunavir/ritonavir plus oseltamivir vs. favipiravir plus lopinavir/ritonavir vs. darunavir/ritonavir plus oseltamivir plus chloroquine vs. darunavir/ritonavir plus favipiravir plus oseltamivir in patients with moderate to severe COVID-19. |
T142 |
5036-5085 |
Sentence |
denotes |
Open-label RCT (NCT04303299, not yet recruiting). |
T143 |
5086-5153 |
Sentence |
denotes |
Primary endpoint: SARS-CoV-2 eradication time (follow-up 24 weeks). |