| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T41 |
0-85 |
Sentence |
denotes |
Zika virus (ZIKV), a single-stranded RNA virus, is a mosquito transmitted flavivirus. |
| T42 |
86-242 |
Sentence |
denotes |
A study using HUVECs and human retinal vascular endothelial cells (HRvECs) showed that AMPK restricts the replication of ZIKV in the endothelial cells [16]. |
| T43 |
243-418 |
Sentence |
denotes |
Activation of AMPK with the help of two well-known AMPK activators, metformin and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) led to attenuation of ZIKV replication. |
| T44 |
419-613 |
Sentence |
denotes |
Activated AMPK further potentiated the expression of certain genes with known antiviral properties such as IFNs, OAS2, ISG15, and MX1 while inhibiting inflammatory mediators like TNF-α and CCL5. |
| T45 |
614-688 |
Sentence |
denotes |
It would be useful to explore whether the same is observed for SARS-CoV-2. |
| T46 |
689-848 |
Sentence |
denotes |
A recent study has reported that inhibition of glycolysis by non-toxic concentration of 2-DG completely attenuated SARS-CoV-2 replication in Caco-2 cells [17]. |
| T47 |
849-935 |
Sentence |
denotes |
All of these indicate towards a possible frontline role of metformin against COVID-19. |
