Id |
Subject |
Object |
Predicate |
Lexical cue |
T3 |
0-112 |
Sentence |
denotes |
A new virus termed SARS-COV-2 (causing COVID-19 disease) can exhibit a progressive, fatal impact on individuals. |
T4 |
113-210 |
Sentence |
denotes |
The World Health Organization (WHO) has declared the spread of the virus to be a global pandemic. |
T5 |
211-304 |
Sentence |
denotes |
Currently, there are over 1 million cases and over 100,000 confirmed deaths due to the virus. |
T6 |
305-372 |
Sentence |
denotes |
Hence, prophylactic and therapeutic strategies are promptly needed. |
T7 |
373-471 |
Sentence |
denotes |
In this study we report an epitope, ITLCFTLKR, which is biochemically fit to HLA allelic proteins. |
T8 |
472-559 |
Sentence |
denotes |
We propose that this could be used as a potential vaccine candidate against SARS-COV-2. |
T9 |
560-694 |
Sentence |
denotes |
A selected putative epitope and HLA-allelic complexes show not only better binding scores, but also RMSD values in the range of 0–1 Å. |
T10 |
695-792 |
Sentence |
denotes |
This epitope was found to have a 99.8% structural favorability as per Ramachandran-plot analysis. |
T11 |
793-932 |
Sentence |
denotes |
Similarly, a suitable range of IC50 values and population coverage was obtained to represent greater validation of T-cell epitope analysis. |
T12 |
933-1061 |
Sentence |
denotes |
Stability analysis using MDWeb and half-life analysis using the ProtParam tool has confirmed that this epitope is well-selected. |
T13 |
1062-1204 |
Sentence |
denotes |
This new methodology of epitope-based vaccine prediction is fundamental and fast in application, ad can be economically beneficial and viable. |