Id |
Subject |
Object |
Predicate |
Lexical cue |
T242 |
0-301 |
Sentence |
denotes |
The overall use of heparin in these patients was also suggested by the management document from the World Health Organization.13 Although this protocol implementation was used for the last 5 patients, and the conclusions might not be generalizable, we did not observe any new thrombotic complications. |
T243 |
302-345 |
Sentence |
denotes |
In addition, none of these 5 patients died. |
T244 |
346-468 |
Sentence |
denotes |
The potential beneficial effect of heparin in our COVID-19 surgical patients might find some support in experimental data. |
T245 |
469-919 |
Sentence |
denotes |
First, plenty of data have shown that heparin is the most effective method for the prevention of thromboembolism.14 Second, it is well-known that heparin has suppressive activity against the development of a cytokines storm, which is a typical pathogenetic process of COVID-19 infection that eventually results in acute lung injury and death.15 , 16 Finally, it has already been shown that heparin has competitive binding activity to the coronavirus. |
T246 |
920-1131 |
Sentence |
denotes |
This final aspect might result in a significant reduction of the pathogen's activity, which would bind to the heparin, instead of attacking the cells of the organism by inhibiting cell penetration.17, 18, 19, 20 |