LitCovid-sentences  

PMC:7172841 / 2063-4855 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T20 0-12 Sentence denotes Introduction
T21 13-134 Sentence denotes In December 2019, authorities in Wuhan, China reported a cluster of pneumonia cases caused by an unknown etiologic agent.
T22 135-331 Sentence denotes The pathogen was soon identified and sequenced as a novel coronavirus related to the agent of severe acute respiratory syndrome (SARS) and was subsequently termed SARS Coronavirus-19 (SARS-CoV-2).
T23 332-459 Sentence denotes The infection spread in the subsequent 3 months on all continents and was declared a pandemic by the World Health Organization.
T24 460-626 Sentence denotes As of April 2, 2020, 961,818 documented cases were reported worldwide, and 49,165 patients had died (https://www.who.int/emergencies/diseases/novel-coronavirus-2019).
T25 627-721 Sentence denotes This novel coronavirus has a tropism for the lung, causing community-acquired pneumonia (CAP).
T26 722-865 Sentence denotes Some patients with pneumonia suddenly deteriorate into severe respiratory failure (SRF) and require intubation and mechanical ventilation (MV).
T27 866-950 Sentence denotes The risk of death of these patients is high, reaching even 60% (Arabi et al., 2020).
T28 951-1023 Sentence denotes Proper management mandates better understanding of disease pathogenesis.
T29 1024-1178 Sentence denotes The majority of physicians use sepsis as a prototype of critical illness for the understanding of severe coronavirus disease 2019 (COVID-19) pathogenesis.
T30 1179-1295 Sentence denotes This is mostly because severe COVID-19 is associated with hyper-cytokinemia (Guan et al., 2020, Huang et al., 2020).
T31 1296-1391 Sentence denotes Lethal sepsis is commonly arising from bacterial CAP, often leading to SRF and the need for MV.
T32 1392-1678 Sentence denotes The peculiar clinical course of CAP caused by SARS-CoV-2, including the sudden deterioration of the clinical condition 7–8 days after the first symptoms, generates the hypothesis that this illness is driven by a unique pattern of immune dysfunction that is likely different from sepsis.
T33 1679-1846 Sentence denotes The features of lymphopenia with hepatic dysfunction and increase of D-dimers (Qin et al., 2020) in these patients with severe disease further support this hypothesis.
T34 1847-2256 Sentence denotes Immune responses of critically ill patients with sepsis can be classified into three patterns: macrophage-activation syndrome (MAS) (Kyriazopoulou et al., 2017), sepsis-induced immunoparalysis characterized by low expression of the human leukocyte antigen D related (HLA-DR) on CD14 monocytes (Lukaszewicz et al., 2009), and an intermediate functional state of the immune system lacking obvious dysregulation.
T35 2257-2355 Sentence denotes We investigated whether this classification might apply to patients with SRF caused by SARS-CoV-2.
T36 2356-2662 Sentence denotes Results revealed that approximately one fourth of patients with SRF have MAS and that most patients suffer from immune dysregulation dominated by low expression of HLA-DR on CD14 monocytes, which is triggered by monocyte hyperactivation, excessive release of interleukin-6 (IL-6), and profound lymphopenia.
T37 2663-2792 Sentence denotes This pattern is distinct from the immunoparalysis state reported in either bacterial sepsis or SRF caused by 2009 H1N1 influenza.