LitCovid-sentences  

PMC:7172841 / 17004-20178 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T134 0-171 Sentence denotes Sepsis-induced immunoparalysis is characterized by profound deficiency of monocytes for cytokine production upon ex vivo stimulation (Giamarellos-Bourboulis et al., 2011).
T135 172-428 Sentence denotes Indeed, production of tumor necrosis factor-α (TNF-α) by LPS-stimulated peripheral blood mononuclear cells (PBMCs) of patients with bacterial CAP classified for immunoparalysis was significantly lower than in patients at an intermediate state (Figure 4 A).
T136 429-588 Sentence denotes That was not the case for patients with pneumonia caused by SARS-CoV-2, in whom PBMCs showed sustained TNF-α production after stimulation with LPS (Figure 4B).
T137 589-763 Sentence denotes The function of PBMCs in patients with SRF caused by 2009H1N1 was also impaired, and there was lower TNF-α production, a pattern different from COVID-19 patients (Figure 4C).
T138 764-920 Sentence denotes Surprisingly, stimulation of IL-1β was lower among patients with immune dysregulation than among patients with an intermediate immune state (Figures 4D–4F).
T139 921-994 Sentence denotes IL-6, however, followed the stimulation pattern of TNF-α (Figures 4G–4I).
T140 995-1293 Sentence denotes This generated the hypothesis that in the case of SRF-aggravated pneumonia caused by SARS-CoV-2, there is a unique combination of defective antigen presentation and lymphopenia that leads to defective function of lymphoid cells, whereas monocytes remain potent for the production of TNF-α and IL-6.
T141 1294-1374 Sentence denotes Figure 4 Main Features of Immune Dysregulation of Pneumonia Caused by SARS-CoV-2
T142 1375-1532 Sentence denotes (A) Production of TNF-α by PBMCs of patients with sepsis caused by bacterial CAP classified into intermediate state of immune activation and immunoparalysis.
T143 1533-1696 Sentence denotes (B) Production of TNF-α by PBMCs of patients with CAP caused by SARS-CoV-2 classified into three states of immune activation: intermediate, dysregulation, and MAS.
T144 1697-1825 Sentence denotes (C) Production of TNF-α by PBMCs of patients with SRF developing after infection caused by the 2009H1N1 virus and by SARS-CoV-2.
T145 1826-1983 Sentence denotes (D) Production of IL-1β by PBMCs of patients with sepsis caused by bacterial CAP classified into intermediate state of immune activation and immunoparalysis.
T146 1984-2147 Sentence denotes (E) Production of IL-1β by PBMCs of patients with CAP caused by SARS-CoV-2 classified into three states of immune activation: intermediate, dysregulation, and MAS.
T147 2148-2276 Sentence denotes (F) Production of IL-1β by PBMCs of patients with SRF developing after infection caused by the 2009H1N1 virus and by SARS-CoV-2.
T148 2277-2433 Sentence denotes (G) Production of IL-6 by PBMCs of patients with sepsis caused by bacterial CAP classified into intermediate state of immune activation and immunoparalysis.
T149 2434-2589 Sentence denotes (H) Production of IL-6 by PBMCs of patients with CAP caused by SARS-CoV-2 classified into states of immune activation: intermediate, dysregulation and MAS.
T150 2590-2717 Sentence denotes (I) Production of IL-6 by PBMCs of patients with SRF developing after infection caused by the 2009H1N1 virus and by SARS-CoV-2.
T151 2718-2885 Sentence denotes (J–L) Serum amounts of TNF-α, IL-6, and CRP of patients with CAP caused by SARS-CoV-2 classified into states of immune activation: intermediate, dysregulation and MAS.
T152 2886-2949 Sentence denotes Bars in each graphic represent mean values and standard errors.
T153 2950-3076 Sentence denotes Statistical comparisons are indicated by the arrows; ns: non-significant; ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
T154 3077-3174 Sentence denotes Comparisons were done by the Mann-Whitney U test followed by correction for multiple comparisons.