LitCovid-sentences  

PMC:7172841 / 10481-13310 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T86 0-119 Sentence denotes Immunoparalysis of sepsis is characterized by significant decrease of the number of HLA-DR molecules on CD14 monocytes.
T87 120-203 Sentence denotes This also happens in immune dysregulation caused by SARS-CoV-2 (Figures 1A and 1B).
T88 204-375 Sentence denotes Although patients with bacterial-CAP-associated MAS also have decreased HLA-DR molecules on CD14 monocytes, their circulating ferritin is significantly higher than normal.
T89 376-459 Sentence denotes This is a feature found only in a few patients with SARS-CoV-2 and MAS (Figure 1C).
T90 460-602 Sentence denotes The absence of traits of MAS among cases of SARS-CoV-2 with immune dysregulation is further proven by the low scores of hemophagocytosis (HS).
T91 603-735 Sentence denotes HScore is proposed as a classification tool for secondary MAS, and values more than 169 are highly diagnostic (Fardet et al., 2014).
T92 736-857 Sentence denotes Seven patients with SARS-CoV-2 had HS above this cut-off, and all were properly classified by using ferritin (Figure 1D).
T93 858-1018 Sentence denotes Among patients with bacterial CAP at an intermediate immune state, the number of molecules of HLA-DR on their CD14 monocytes was lower than in healthy patients.
T94 1019-1207 Sentence denotes However, patients with pneumonia caused by SARS-CoV-2 at an intermediate immune state maintained their number of molecules of HLA-DR on CD14 monocytes much closer to the healthy condition.
T95 1208-1278 Sentence denotes When this number suddenly dropped, SRF supervened (Figures 1A and 1B).
T96 1279-1434 Sentence denotes Moreover, the absolute counts of neutrophils and monocytes were higher among patients with immune dysregulation than patients with MAS (Figures 1E and 1F).
T97 1435-1495 Sentence denotes Figure 1 Characteristics of Immune Dysregulation of COVID-19
T98 1496-1593 Sentence denotes (A) Absolute numbers of the molecules of the human leukocyte antigen (mHLA-DR) on CD14 monocytes.
T99 1594-1794 Sentence denotes Patients with bacterial CAP and CAP caused by SARS-CoV-2 are classified into three states of immune activation: intermediate, immunoparalysis for bacterial CAP and dysregulation for COVID-19, and MAS.
T100 1795-1986 Sentence denotes (B) Mean fluorescence intensity (MFI) of HLA-DR on CD14 monocytes of healthy volunteers and of patients with CAP caused by SARS-CoV-2 classified according to their state of immune activation.
T101 1987-2144 Sentence denotes (C) Ferritin concentrations in the serum of patients with bacterial CAP and sepsis and CAP caused by SAR-CoV-2 according to their state of immune activation.
T102 2145-2274 Sentence denotes (D) Hemophagocytosis score among patients with CAP caused by SARS-CoV-2 classified according to their state of immune activation.
T103 2275-2408 Sentence denotes (E) Absolute neutrophil counts among patients with CAP caused by SARS-CoV-2 classified according to their state of immune activation.
T104 2409-2540 Sentence denotes (F) Absolute monocyte counts among patients with CAP caused by SARS-CoV-2 classified according to their state of immune activation.
T105 2541-2604 Sentence denotes Bars in each graphic represent mean values and standard errors.
T106 2605-2731 Sentence denotes Statistical comparisons are indicated by the arrows; ns: non-significant; ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
T107 2732-2829 Sentence denotes Comparisons were done by the Mann-Whitney U test followed by correction for multiple comparisons.