LitCovid-sentences  

PMC:7170368 / 5085-9307 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T45 0-7 Sentence denotes Results
T46 8-118 Sentence denotes A total of 417 COVID-19 patients were admitted to the Shenzhen Third People’s Hospital as of 23 February 2020.
T47 119-170 Sentence denotes Among these patients, 51 (12.23%) had hypertension.
T48 171-328 Sentence denotes Nine patients (17.6%) with Grade 1hypertension did not take any antihypertensive drugs during hospitalization and were excluded from the subsequent analysis.
T49 329-427 Sentence denotes The other 42 patients (82.4%) receiving antihypertensive therapy were included in further studies.
T50 428-772 Sentence denotes The 42 analyzed patients were divided into two groups based on antihypertensive therapies: the ACEI/ARB group (17 patients) included patients treated with ACEI or ARB drugs, and the non-ACEI/ARB group (25 patients) included patients treated with other antihypertensive drugs, including calcium channel blockers (CCBs), β-blockers and diuretics.
T51 773-953 Sentence denotes Eight patients (32%) in the non-ACEI/ARB group and 5 patients (29.41%)in the ACEI/ARB group had other comorbidities, such as type 2 diabetes (T2D) and coronary heart disease (CHD).
T52 954-1093 Sentence denotes The vast majority of hypertensive patients had received the current therapeutic regimens shown in supplementary Table S1 for over one year.
T53 1094-1204 Sentence denotes The blood pressure of patients was well-controlled with the above therapeutic regimens during hospitalization.
T54 1205-1311 Sentence denotes The comparison of baseline characteristics between the two groups is summarized in supplementary Table S2.
T55 1312-1420 Sentence denotes The median age of the analyzed subjects was 64.5 years (IQR, 55.8–69.0 years), and 57.1% of them were males.
T56 1421-1539 Sentence denotes No significant differences in hypertension grades were observed between the ACEI/ARB group and the non-ACEI/ARB group.
T57 1540-1586 Sentence denotes Both groups showed similar signs and symptoms.
T58 1587-1726 Sentence denotes The median number of days from the onset of symptoms to hospital admission was 2.0 in the non-ACEI/ARB group and 3.0 in the ACEI/ARB group.
T59 1727-1881 Sentence denotes Meanwhile, the median number of days from symptom onset to hospital discharge was 16.5 days in the non-ACEI/ARB group and 20.0 days in the ACEI/ARB group.
T60 1882-1990 Sentence denotes The median heart rate and respiratory rate from the non-ACEI/ARB group were 90.5 bpm and 20.0, respectively.
T61 1991-2114 Sentence denotes In comparison, the median heart rate and respiratory rate from the non-ACEI/ARB group were 80.0 bmp and 20.0, respectively.
T62 2115-2218 Sentence denotes All baseline characteristics shown in Table S2 were not significantly different between the two groups.
T63 2219-2347 Sentence denotes During hospitalization, 12 patients in the non-ACEI/ARB group (48%) were categorized into severe subgroups and one patient died.
T64 2348-2482 Sentence denotes In contrast, in the ACEI/ARB group, only 4 patients (23.5%) were categorized into severe subgroups and no patients died (Figure 1(A)).
T65 2483-2676 Sentence denotes The percentage of severe cases in the ACEI/ARB group was higher than that in the non-ACEI/ARB group, but this difference was not significant, possibly due to the small number of clinical cases.
T66 2677-2796 Sentence denotes We next examined the effects of taking ACEI or ARB drugs on laboratory findings of COVID-19 patients with hypertension.
T67 2797-2901 Sentence denotes As shown in Figure 1(B), there was a trend toward lower IL-6 levels in patients from the ACEI/ARB group.
T68 2902-3000 Sentence denotes No marked variation in C-reactive protein (CRP) was observed between the two groups (Figure 1(B)).
T69 3001-3129 Sentence denotes The absolute number of CD3+ and CD8+ T cells in the ACEI/ARB group was significantly higher than that in the non-ACEI/ARB group.
T70 3130-3223 Sentence denotes There were no significant changes in CD4+ T cell counts between the two groups (Figure 1(C)).
T71 3224-3464 Sentence denotes In addition, although the viral load was not different between the two groups at hospital admission, the peak viral load during hospitalization in the ACEI/ARB group was significantly lower than that in the non-ACEI/ARB group (Figure 1(D)).
T72 3465-3693 Sentence denotes Other laboratory findings, such as white blood cell counts, neutrophil counts, platelet counts, and lactate dehydrogenase, are shown in supplementary Table S3, and no significant differences were observed between the two groups.
T73 3694-3703 Sentence denotes Figure 1.
T74 3704-4106 Sentence denotes Summarized clinical, inflammatory, immunological, and viral findings in the non-ACEI/ARB group and the ACE/ARB group. (A) The disease severity distribution of the two groups during hospitalization. (B) The levels of IL-6 and CRP in peripheral blood. (C) Absolute numbers of CD3+, CD4+, and CD8+ T cells in peripheral blood. (D) Viral load on hospital admission and maximum value during hospitalization.
T75 4107-4152 Sentence denotes The data are expressed as the median and IQR.
T76 4153-4222 Sentence denotes An unpaired t test was used, and P < 0.05 was considered significant.