LitCovid-sentences  

PMC:7170368 / 1064-3047 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T12 0-12 Sentence denotes Introduction
T13 13-174 Sentence denotes The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to endanger global health and to hamper the world economy.
T14 175-239 Sentence denotes This outbreak started in December 2019 in Wuhan, Hubei Province.
T15 240-330 Sentence denotes Unfortunately, currently, there is still no specific and effective treatment for COVID-19.
T16 331-489 Sentence denotes Evidence shows that elderly people with SARS-CoV-2 infections and cardiovascular diseases, including hypertension, are at risk of developing severe cases [1].
T17 490-687 Sentence denotes A hypertension survey from 2012 to 2015 reported that 23.2% of Chinese people ≥18 years of age had hypertension, whereas the prevalence of hypertension was >55% among citizens ≥65 years of age [2].
T18 688-873 Sentence denotes RAS plays an important role in regulating electrolyte balance and blood pressure and comprises two pathways: the ACE/Ang II/AT1R pathway and the ACE2/Ang (1–7)/Mas receptor pathway [3].
T19 874-1091 Sentence denotes Under normal physiological conditions, the activity of the ACE/Ang II/AT1R axis and the ACE2/Ang (1–7)/Mas receptor axis are in a dynamic equilibrium state, maintaining the normal function of the corresponding system.
T20 1092-1192 Sentence denotes Similar to SARS, SARS-CoV-2 is believed to invade the host through the cell entry receptor ACE2 [4].
T21 1193-1341 Sentence denotes SARS-CoV infections reduce ACE2 expression, resulting in an imbalance between the ACE/Ang II/AT1R axis and the ACE2/Ang (1–7)/Mas receptor axis [5].
T22 1342-1426 Sentence denotes Targeting the ACE/Ang II/AT1R axis is a novel therapeutic strategy for hypertension.
T23 1427-1549 Sentence denotes ACEIs and ARAs not only inhibit the ACE/Ang II/AT1R pathway but also modulate the ACE2/Ang (1–7)/Mas receptor pathway [6].
T24 1550-1867 Sentence denotes The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown.
T25 1868-1983 Sentence denotes Here, we aimed to evaluate the ability of RAS inhibitors to protect against COVID-19 in patients with hypertension.