LitCovid-sentences  

PMC:7164855 / 812-5264 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T9 0-164 Sentence denotes A novel coronavirus — officially named as severe acute respiratory syndrome (SARS)-CoV-2 by the authorities — emerged in Wuhan, China, toward the end of 2019 [1,2].
T10 165-336 Sentence denotes Just four months later, more than 100,000 cases have been diagnosed with the resulting disease, COVID-19, in more than 100 countries at the time of writing this paper [3].
T11 337-527 Sentence denotes Not only does mainland China have the most number of reported cases (94.4%), but its case-fatality rate is also relatively higher than that of other countries as of February 28, 2020 (China:
T12 528-592 Sentence denotes 3.5%, 2791 deaths among 78,961 confirmed cases; other countries:
T13 593-641 Sentence denotes 1.4%, 67 deaths among 4691 confirmed cases) [4].
T14 642-880 Sentence denotes In an attempt to restrict the outbreak, China quickly implemented an unprecedented measure of quarantining 35 million people in Wuhan and several other cities, but its impact on slowing the global spread of the virus now seems inadequate.
T15 881-1002 Sentence denotes In fact, the number of cases in local human-to-human transmission kept soaring in several countries as of March 25, 2020:
T16 1003-1089 Sentence denotes Italy 63,927 cases, United States of America 42,164 cases, and Spain 33,089 cases [3].
T17 1090-1243 Sentence denotes In Japan, 1128 cases were confirmed based on positive viral nucleic acid test results, and the overall case-fatality rate was 3.7% (i.e., 42 deaths) [3].
T18 1244-1392 Sentence denotes Quite some information about the viral biology of SARS-CoV-2 and clinical characteristics of COVID-19 has been reported in the past few weeks [1,2].
T19 1393-1783 Sentence denotes The genetic analysis of SARS-CoV-2 revealed that this virus is a new Betacoronavirus in close proximity to bat-derived SARS-like coronaviruses, and that SARS-CoV-2 has clear zoonotic origins, probably arising through adaptations caused by genetic mutation and recombination between different strains of coronaviruses in pangolins whose scales are used in traditional Chinese medicine [5,6].
T20 1784-1992 Sentence denotes The genomic characterization also showed that SARS-CoV-2 shares angiotensin-converting enzyme 2 (ACE2) receptors with SARS-CoV, which was the Betacoronavirus responsible for the global outbreak in 2002 [1,2].
T21 1993-2249 Sentence denotes For both coronaviruses, binding to ACE2, which is expressed on ciliated bronchial epithelial cells and type II pneumocytes, may be a critical determinant not only for clinical manifestations (i.e., pulmonary involvement) but also for transmission capacity.
T22 2250-2411 Sentence denotes In fact, a strain of SARS-CoV with higher affinity for ACE2 was proved to have higher efficiency of infection in human cells and transmission between humans [7].
T23 2412-2572 Sentence denotes The binding affinity for ACE2 may explain why SARS-CoV-2 is more easily transmissible than SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV).
T24 2573-2731 Sentence denotes The basic reproduction number (R 0, the expected number of secondary cases produced by one infected case) for SARS-CoV-2 is estimated to be more than 2 [1,8].
T25 2732-2915 Sentence denotes Clinical data from hospitals in China have revealed that 87% COVID-19 patients were aged 30–79 years and approximately 10% of the patients had severe disease requiring intensive care.
T26 2916-3139 Sentence denotes Additionally, such patients with severe clinical manifestation are typically characterized by older adults with comorbid conditions such as cardiovascular disease, chronic respiratory disease, or diabetes [[9], [10], [11]].
T27 3140-3424 Sentence denotes Because of the lack of epidemiologic data regarding diagnostic tests for COVID-19 on a population level, this figure may overlook many infected patients with subclinical or mild disease who are unlikely to seek health care, representing just the tip of a possibly large iceberg [1,2].
T28 3425-3583 Sentence denotes Substantially greater epidemiologic information is the key to get an accurate handle on whether COVID-19 is less alarming than what has been portrayed so far.
T29 3584-3723 Sentence denotes Moreover, even carriers with no or few symptoms appear to possess transmission potential of COVID-19 infection by shedding the virus [1,2].
T30 3724-4009 Sentence denotes Owing to the ineffective containment of the outbreak due to such asymptomatic transmission, there is an urgent need to accelerate the development of rapid point-of-care diagnostic tests, vaccines, and therapeutics for COVID-19 that is proving to be an epidemic in the human population.
T31 4011-4044 Sentence denotes Declaration of Competing Interest
T32 4045-4123 Sentence denotes Toshiaki Kikuchi received a research grant from 10.13039/100004325AstraZeneca.
T33 4124-4320 Sentence denotes Toshiaki Kikuchi received lecture fees from 10.13039/100010793Pfizer Japan, Daiichi Sankyo, 10.13039/100010795Chugai Pharmaceutical, Nippon 10.13039/100001003Boehringer Ingelheim, and AstraZeneca.
T34 4321-4452 Sentence denotes Toshiaki Kikuchi received subsidies from Chugai Pharmaceutical, 10.13039/100014422Eli Lilly Japan, and Nippon Boehringer Ingelheim.