LitCovid-sentences  

PMC:7161517 / 9777-11799 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T68 0-212 Sentence denotes Because of the importance of the RAS in cardiovascular disease, its regulation via ACE inhibitors, ARBs, and MRAs has played an essential role in the management of cardiovascular diseases (Central Illustration ).
T69 213-288 Sentence denotes Central Illustration The Renin-Angiotensin System Interaction With COVID-19
T70 289-428 Sentence denotes Normally, angiotensin I (Ang I) is converted to Ang II via angiotensin-converting enzyme (ACE), which could be inhibited by ACE inhibitors.
T71 429-510 Sentence denotes The pro-inflammatory effects of Ang II are mediated through AT1R in several ways:
T72 511-996 Sentence denotes 1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis.
T73 997-1102 Sentence denotes These effects are attenuated by angiotensin receptor blockers (ARBs), which block Ang II binding to AT1R.
T74 1103-1242 Sentence denotes Ang II can also be converted to angiotensin 1-7 (Ang 1-7) via ACE2, which stimulates the Mas receptor promoting anti-inflammatory benefits.
T75 1243-1355 Sentence denotes The ACE2/Ang1-7/Mas axis acts as a counter regulatory pathway to the traditional renin-angiotensin system (RAS).
T76 1356-1382 Sentence denotes AT1R and ACE2 are coupled.
T77 1383-1461 Sentence denotes Ang II binding to AT1R allows dissociation of ACE2 and subsequent degradation.
T78 1462-1564 Sentence denotes ARB prevents dissociation of ACE2 and renders it availability for unused Ang II conversion to Ang 1-7.
T79 1565-1700 Sentence denotes ACE2 has been identified as the targeted receptor for both the severe acute respiratory syndrome coronavirus (SARS-CoV) 2 and SARS-CoV.
T80 1701-1831 Sentence denotes ACE2 mediates S protein binding that stimulates viral entry into the host cytosol that results in infection and viral replication.
T81 1832-2022 Sentence denotes Diversion of Ang II towards ACE2 could competitively inhibit viral binding and also counter regulate the adverse effects caused by AT1R and improve outcomes by Mas R−based favorable effects.