LitCovid-sentences  

PMC:7161517 / 4247-5889 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T29 0-31 Sentence denotes Angiotensin-Converting Enzyme 2
T30 32-132 Sentence denotes Classically, the RAS involves the conversion of angiotensinogen by renin into angiotensin I (Ang I).
T31 133-203 Sentence denotes Ang I is metabolized to Ang II via the dipeptide carboxypeptidase ACE.
T32 204-304 Sentence denotes The pro-inflammatory effects of Ang II (7, 8, 9) are mediated through Ang II type I (AT1) receptors.
T33 305-439 Sentence denotes Recently, the ACE2 receptor and its signaling pathway were identified as an important counter regulatory mechanism to the classic RAS.
T34 440-615 Sentence denotes ACE2 is a type I integral membrane glycoprotein (15) expressed predominantly in the bronchus, lung parenchyma, heart, endothelium, kidneys, duodenum, and small intestine (16).
T35 616-744 Sentence denotes ACE2 is a monocarboxypeptidase, unlike its homolog, ACE, which is a dipeptidase; ACE2 is not antagonized by ACE inhibitors (17).
T36 745-866 Sentence denotes Although ACE contains 2 active catalytic domains, ACE2 has a single catalytic domain with 42% identical residues (18,19).
T37 867-997 Sentence denotes The major substrate of ACE2 is Ang II, which upon C-terminus cleavage, produces angiotensin 1-7 (Ang1-7) and L-phenylalanine (20).
T38 998-1118 Sentence denotes Other substrates for ACE2 include Ang I, apelin-13, and dynorphin-13, which are catalyzed at much lower affinities (21).
T39 1119-1307 Sentence denotes The non-catalytic C-terminal domain of ACE2 shares a 48% sequence homology with collectrin, a protein involved in neutral amino acid reabsorption from the intestine and the kidney (22,23).
T40 1308-1537 Sentence denotes In the presence of a disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor (TNF)-α−converting enzyme (TACE), ACE2 exhibits ectodomain shedding (24), which results in the formation of a soluble enzyme.
T41 1538-1642 Sentence denotes ACE2 also contains a calmodulin domain on its cytoplasmic tail that influences ectodomain shedding (25).