| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T189 |
0-271 |
Sentence |
denotes |
Lipopolysaccharide-induced acute lung injury mouse models exhibited decreased expression of ACE2, lung and inflammatory injury; however, this was ameliorated by the injection of cells transfected with ACE2 and resulted in the improvement of lung function and lung injury. |
| T190 |
272-390 |
Sentence |
denotes |
Treatment of these mice with ACE inhibitors and ARBs also alleviated lipopolysaccharide-induced pneumonic injury (67). |
| T191 |
391-505 |
Sentence |
denotes |
Previous studies showed the SARS-CoV S protein can exaggerate acute lung failure through dysregulation of the RAS. |
| T192 |
506-608 |
Sentence |
denotes |
However, SARS-CoV Spike–mediated lung failure could be rescued by inhibition of the AT1 receptor (67). |
| T193 |
609-893 |
Sentence |
denotes |
Again, adequate data on the effects of RAS inhibition in patients with COVID-19 is not available, and ongoing clinical and/or observations studies are being conducted (see previous mentions of NCT04318301, NCT04318418, NCT04312009, NCT04311177, NCT04287686, NCT04330300, NCT04329195). |
