| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T164 |
0-60 |
Sentence |
denotes |
Figure 2 Proposed Mechanism of Entry for SARS-CoV-2 Via ACE2 |
| T165 |
61-176 |
Sentence |
denotes |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the catalytic site of ACE2 via its S protein. |
| T166 |
177-411 |
Sentence |
denotes |
To gain access to the host cytosol, the S protein undergoes acid dependent proteolytic cleavage by ACE2, tumor necrosis factor (TNF)-α, transmembrane protease serine 2 (TMPRRS2), which results in the formation of an S1 and S2 subunit. |
| T167 |
412-525 |
Sentence |
denotes |
S2 fusion peptide inserts into the membrane, which allows for clatherin-dependent endocytosis of ACE2-SARS-CoV-2. |
| T168 |
526-622 |
Sentence |
denotes |
Viral binding stimulates TNF-α and calmodulin inhibitors to promote ectodomain cleavage of ACE2. |
| T169 |
623-704 |
Sentence |
denotes |
ADAM 17 = disintegrin and metalloprotease 17; other abbreviations as in Figure 1. |
