| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T113 |
0-55 |
Sentence |
denotes |
The mechanisms by which ACE inhibitors act are complex. |
| T114 |
56-208 |
Sentence |
denotes |
Although ACE2 is not inhibited by ACE inhibitors (19), an increase in Ang1-7 suggests their clinical effects are partly mediated by the angiotensinases. |
| T115 |
209-307 |
Sentence |
denotes |
ACE inhibitors inhibit the conversion of Ang I to Ang II and inhibit the hydrolysis of bradykinin. |
| T116 |
308-530 |
Sentence |
denotes |
ACE inhibition promotes the vasodilatory effects of bradykinin, improved endothelium-dependent vasodilation through increased prostaglandin and nitric oxide production, and down regulation of the AT1 receptor (50, 51, 52). |
| T117 |
531-691 |
Sentence |
denotes |
Studies that elucidated the effect of ACE inhibition on the ACE2 gene showed that inhibition of Ang II synthesis regulated ACE2 mRNA but not ACE2 activity (53). |
| T118 |
692-831 |
Sentence |
denotes |
However, ACE inhibition alone or in combination with losartan was demonstrated to increase plasma Ang1-7 while reducing plasma Ang II (53). |
| T119 |
832-1103 |
Sentence |
denotes |
Compared with the degree of ACE2 mRNA upregulation seen with post-losartan monotherapy, combination of losartan and lisinopril resulted in suppressed upregulation of ACE2 mRNA, which suggested ACE inhibitors might override a signal that regulates ACE2 transcription (53). |
| T120 |
1104-1385 |
Sentence |
denotes |
Although Ang II is the predominant substrate, ACE2 can also convert Ang I into Ang 1-9, which, in turn, could be converted to Ang 1-7 via ACE; Ang I can be directly converted into Ang 1-7 via zinc metallopeptidase neprilysin (17), although with less favorable kinetics at baseline. |
| T121 |
1386-1548 |
Sentence |
denotes |
Thus, it can be assumed ACE inhibitors disrupt the balance between catalytically active ACE and ACE2, resulting in favored activation of the ACE2/Ang1-7/Mas axis. |
