LitCovid-sentences  

PMC:7161517 / 11800-13807 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T82 0-109 Sentence denotes Several studies have elucidated the role of these drug classes on the modulation of the ACE2/Ang1-7/Mas axis.
T83 110-275 Sentence denotes Mouse peritoneal macrophages treated in vitro with aldosterone, demonstrated significantly increased ACE activity as well as ACE mRNA and significantly reduced ACE2.
T84 276-558 Sentence denotes However, in mouse peritoneal macrophages treated with nicotinamide adenine dinucleotide phosphate oxidase inhibitor, aldosterone could not increase ACE or decrease ACE2, which suggested these effects were mediated in part by nicotinamide adenine dinucleotide phosphate oxidase (42).
T85 559-639 Sentence denotes These effects were also attenuated with treatment with an MRA (eplerenone) (42).
T86 640-878 Sentence denotes Human monocyte-derived macrophages obtained from patients with heart failure before and after 1 month of treatment with another MRA (spironolactone; 25 mg/day) showed 47% reduction in ACE activity and 53% reduction in ACE mRNA expression.
T87 879-977 Sentence denotes At the same time, ACE2 activity increased by 300% and ACE2 mRNA expression increased by 654% (42).
T88 978-1128 Sentence denotes In mice treated for 2 weeks with eplerenone, cardiac ACE2 activity increased 2-fold and was paralleled by increased ACE2 activity in macrophages (42).
T89 1129-1375 Sentence denotes This study demonstrated that the MRA reduced oxidative stress, decreased ACE activity, and increased ACE2 activity and/or expression, which suggested the protective role played by increased generation of Ang 1-7 and decreased formation of Ang II.
T90 1376-1704 Sentence denotes Overall, aldosterone decreased ACE2 transcription through a nicotinamide adenine dinucleotide phosphate oxidase−mediated pathway (42), and in vascular smooth muscle cells, potentiated Ang II signaling with increased phosphorylation of ERK1/2 and c-Jun kinase, which are also dependent on reactive oxygen species generation (43).
T91 1705-1849 Sentence denotes Thus, the beneficial effects of MRAs are likely associated with reduction of oxidative stress and differential control of these angiotensinases.
T92 1850-2007 Sentence denotes MRAs appeared to promote membrane ACE2 expression and suppress the peripheral effects of Ang II; however, the effect of MRAs on soluble ACE2 remains unclear.