PMC:7160442 / 4446-7981 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T29 0-39 Sentence denotes Knowledge gains and remaining questions
T30 40-262 Sentence denotes The virus causing COVID-19 was identified and announced on 7 January and by 10 January, sequences of five genomes had been shared, providing scientists around the world with a basis for development of diagnostic tests [8].
T31 263-371 Sentence denotes There was fast growing knowledge about several important parameters for understanding the spread of disease.
T32 372-1031 Sentence denotes A number of studies in various settings determined the basic reproductive number R0 to be within the range of 2–3 [9,10]; the incubation period was determined as ranging from 1 to 14 days with an average of 5–6 days; transmission through droplets was established as the main mode of transmission; the clinical picture that emerged included a wide range from mild symptoms with fever, sore throat and cough to severe pneumonias with characteristic features on computed tomography scans; in Hubei, China, up to 13.8% of laboratory-confirmed patients had severe disease, 6.1% were critically ill and the case fatality rate among all COVID-19 cases was 2.3% [11].
T33 1032-1273 Sentence denotes Further questions on topics such as the possibility of asymptomatic transmission, the proportion of asymptomatic infections, stability of the virus in the environment and main risk groups [12] were partly answered as the pandemic progressed.
T34 1274-1499 Sentence denotes Evidence of asymptomatic transmission was documented in several settings and a study based on an outbreak on a cruise ship determined the proportion of asymptomatic infections as 17.9% (95% credible interval: 15.5–20.2) [13].
T35 1500-1593 Sentence denotes Laboratory experiments provided data on the survival of the virus on different surfaces [14].
T36 1594-1771 Sentence denotes Aside from people older than 70 years, severe and fatal cases were seen particularly in men and people with hypertension, diabetes, underlying pulmonary diseases and in smokers.
T37 1772-1918 Sentence denotes Children were shown to be infected with SARS-CoV-2 [15], however, the role of children in disease transmission still needs to be fully elucidated.
T38 1919-2020 Sentence denotes The focus of ongoing research includes determining the duration of virus shedding and infectiousness.
T39 2021-2154 Sentence denotes Development of serological tests with good sensitivity and specificity for wide-scale use is necessary to assess population immunity.
T40 2155-2333 Sentence denotes Serological studies have been started in several European countries to define population immunity and studies on the duration of immunity will need to be conducted in the future.
T41 2334-2457 Sentence denotes Clinical trials are being conducted worldwide to investigate treatment options with a variety of antiviral and other drugs.
T42 2458-2725 Sentence denotes The World Health Organization (WHO) and European Union-funded projects are coordinating multi-centre adaptive trials to assess the effectiveness of remdesivir, hydroxychloroquine and a combination of lopinavir and ritonavir with or without interferon-beta-1a [16,17].
T43 2726-2834 Sentence denotes A number of vaccine trials are ongoing worldwide with earliest results expected within the coming 18 months.
T44 2835-2992 Sentence denotes A number of questions and challenges that arose in the COVID-19 pandemic appear similar to those experienced during the 2009 influenza A(H1N1)pdm09 pandemic.
T45 2993-3359 Sentence denotes However, information sharing by scientists was faster in 2020, also facilitated by international organisations, widespread social media use and policies of a number of scientific journals, including Eurosurveillance, that enabled fast-tracking of peer-reviewed articles, publishing of articles already deposited in pre-print servers, and making articles open access.
T46 3360-3535 Sentence denotes In particular, the global initiative on sharing all influenza data (GISAID) has allowed organisations like nextstrain.org to collectively perform analysis in almost real time.