Id |
Subject |
Object |
Predicate |
Lexical cue |
T29 |
0-39 |
Sentence |
denotes |
Knowledge gains and remaining questions |
T30 |
40-262 |
Sentence |
denotes |
The virus causing COVID-19 was identified and announced on 7 January and by 10 January, sequences of five genomes had been shared, providing scientists around the world with a basis for development of diagnostic tests [8]. |
T31 |
263-371 |
Sentence |
denotes |
There was fast growing knowledge about several important parameters for understanding the spread of disease. |
T32 |
372-1031 |
Sentence |
denotes |
A number of studies in various settings determined the basic reproductive number R0 to be within the range of 2–3 [9,10]; the incubation period was determined as ranging from 1 to 14 days with an average of 5–6 days; transmission through droplets was established as the main mode of transmission; the clinical picture that emerged included a wide range from mild symptoms with fever, sore throat and cough to severe pneumonias with characteristic features on computed tomography scans; in Hubei, China, up to 13.8% of laboratory-confirmed patients had severe disease, 6.1% were critically ill and the case fatality rate among all COVID-19 cases was 2.3% [11]. |
T33 |
1032-1273 |
Sentence |
denotes |
Further questions on topics such as the possibility of asymptomatic transmission, the proportion of asymptomatic infections, stability of the virus in the environment and main risk groups [12] were partly answered as the pandemic progressed. |
T34 |
1274-1499 |
Sentence |
denotes |
Evidence of asymptomatic transmission was documented in several settings and a study based on an outbreak on a cruise ship determined the proportion of asymptomatic infections as 17.9% (95% credible interval: 15.5–20.2) [13]. |
T35 |
1500-1593 |
Sentence |
denotes |
Laboratory experiments provided data on the survival of the virus on different surfaces [14]. |
T36 |
1594-1771 |
Sentence |
denotes |
Aside from people older than 70 years, severe and fatal cases were seen particularly in men and people with hypertension, diabetes, underlying pulmonary diseases and in smokers. |
T37 |
1772-1918 |
Sentence |
denotes |
Children were shown to be infected with SARS-CoV-2 [15], however, the role of children in disease transmission still needs to be fully elucidated. |
T38 |
1919-2020 |
Sentence |
denotes |
The focus of ongoing research includes determining the duration of virus shedding and infectiousness. |
T39 |
2021-2154 |
Sentence |
denotes |
Development of serological tests with good sensitivity and specificity for wide-scale use is necessary to assess population immunity. |
T40 |
2155-2333 |
Sentence |
denotes |
Serological studies have been started in several European countries to define population immunity and studies on the duration of immunity will need to be conducted in the future. |
T41 |
2334-2457 |
Sentence |
denotes |
Clinical trials are being conducted worldwide to investigate treatment options with a variety of antiviral and other drugs. |
T42 |
2458-2725 |
Sentence |
denotes |
The World Health Organization (WHO) and European Union-funded projects are coordinating multi-centre adaptive trials to assess the effectiveness of remdesivir, hydroxychloroquine and a combination of lopinavir and ritonavir with or without interferon-beta-1a [16,17]. |
T43 |
2726-2834 |
Sentence |
denotes |
A number of vaccine trials are ongoing worldwide with earliest results expected within the coming 18 months. |
T44 |
2835-2992 |
Sentence |
denotes |
A number of questions and challenges that arose in the COVID-19 pandemic appear similar to those experienced during the 2009 influenza A(H1N1)pdm09 pandemic. |
T45 |
2993-3359 |
Sentence |
denotes |
However, information sharing by scientists was faster in 2020, also facilitated by international organisations, widespread social media use and policies of a number of scientific journals, including Eurosurveillance, that enabled fast-tracking of peer-reviewed articles, publishing of articles already deposited in pre-print servers, and making articles open access. |
T46 |
3360-3535 |
Sentence |
denotes |
In particular, the global initiative on sharing all influenza data (GISAID) has allowed organisations like nextstrain.org to collectively perform analysis in almost real time. |