PMC:7156903 / 19630-23900 JSONTXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T148 0-208 Sentence denotes On the frontlines of fighting the COVID-19 epidemic, chest imaging (particularly chest CT) now has an irreplaceable role in the early diagnosis of COVID-19 as well as monitoring the disease’s clinical course.
T149 209-356 Sentence denotes COVID-19 has characteristic manifestations in the lung that are readily detected on chest CT as described in some recent publications [15, 24, 25].
T150 357-551 Sentence denotes In several prior reports, chest CT showed progression of disease that corresponded with worsening clinical symptoms and also disease resolution as the patients clinically recovered [21, 22, 27].
T151 552-731 Sentence denotes In a recent report [20], the predominant pattern of abnormality in COVID-19 observed on the basis of the interval between symptom onset and the first CT scan has some differences.
T152 732-1004 Sentence denotes Lesions quickly evolved from focal unilateral to diffuse bilateral ground glass opacities that progressed to or co-existed with consolidations within 1–3 weeks, indicating the change through clinical course which was also reflected on the number of involved lung segments.
T153 1005-1312 Sentence denotes In a prior study of 51 patients, the absolute number of lung findings increased with the time from symptom onset and lesions with consolidations including ground glass opacities with consolidation and pure consolidation showed mildly positive correlation with the time between symptom onset and the CT [25].
T154 1313-1468 Sentence denotes Another report demonstrated mild or moderate progression of disease as manifested by increasing extent and density of lung opacities during follow-up [24].
T155 1469-1675 Sentence denotes In the context of typical clinical presentation and exposure history, some patients may present with negative results of RT-PCR for COVID-19 but have characteristic imaging features of COVID-19 on chest CT.
T156 1676-1800 Sentence denotes Subsequently, these patients whose labs were initially negative for COVID-19 did test positive later with repeat swab tests.
T157 1801-1967 Sentence denotes Thus, in patients at high risk for COVID-19, chest CT evidence of viral pneumonia may precede negative RT-PCR test results and present as an important warning signal.
T158 1968-2132 Sentence denotes A combination of repeated swab tests and CT scanning may be helpful for individuals with high clinical suspicion of COVID-19 but negative RT-PCR screening [28, 29].
T159 2133-2191 Sentence denotes Chest CT has a high sensitivity for diagnosis of COVID-19.
T160 2192-2423 Sentence denotes In a report of 51 patients with chest CT and RT-PCR assay performed within 3 days, the sensitivity of chest CT was greater than that of RT-PCR for COVID-19 at initial patient presentation (98% vs 71%, respectively, p < 0.001) [30].
T161 2424-2528 Sentence denotes In another study of 1014 patients, 59% had positive RT-PCR results, and 88% had positive chest CT scans.
T162 2529-2621 Sentence denotes The sensitivity of chest CT in suggesting COVID-19 was 97% based on positive RT-PCR results.
T163 2622-2764 Sentence denotes Between 60% and 93% of cases had initial positive CT consistent with COVID-19 prior (or parallel) to the initial positive RT-PCR results [31].
T164 2765-2817 Sentence denotes In addition, chest CT can evaluate disease severity.
T165 2818-3007 Sentence denotes In terms of the percentage of pneumonia lesions in the entire lung volume, the difference between the earlier stage patients and the severe stage patients is statistically significant [32].
T166 3008-3273 Sentence denotes In an initial prospective analysis of the clinical features of 41 patients, chest CT images of ICU patients on admission showed bilateral multiple lobular and subsegmental areas of consolidation, and overall had more imaging abnormalities than non-ICU patients [1].
T167 3274-3402 Sentence denotes Older patients may have more systemic symptoms, more extensive lung involvement, and worse prognosis than younger patients [33].
T168 3403-3614 Sentence denotes Thus, the typical CT findings of COVID-19 can not only help early screening suspected cases, but can also monitor the clinical progression and may predict severe complications such as acute respiratory diseases.
T169 3615-3775 Sentence denotes With high sensitivity for COVID-19, chest CT would play a very important role in the diagnosis and treatment of COVID-19 in the high-risk regions and countries.
T170 3776-3955 Sentence denotes In some extreme situations in very high-risk areas (Wuhan, China), CT was the one of main diagnostic criteria for this disease due to the relatively high false negative of RT-PCR.
T171 3956-4077 Sentence denotes For some low-risk regions and countries, positive predictive value of CT alone or adding CT to RT-PCR should be adjusted.
T172 4078-4133 Sentence denotes The proposition of CT could be tempered to some degree.
T173 4134-4270 Sentence denotes Therefore, to be more accurate, the role of chest CT in COVID-19 should be assessed based on the prevalence of the disease in each area.