LitCovid-sentences  

PMC:7152911 / 62699-65157 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T501 0-106 Sentence denotes While both monoclonal and polyclonal antibodies enable the selective detection of pathogens (Patris et al.
T502 107-189 Sentence denotes 2016), they vary in terms of production method, selectivity, and binding affinity.
T503 190-296 Sentence denotes Monoclonal antibodies are produced by hybridoma technology (Birch and Racher, 2006; James and Bell, 1987).
T504 297-424 Sentence denotes Thus, monoclonal antibodies are highly selective and bind to a single epitope, making them less vulnerable to cross-reactivity.
T505 425-576 Sentence denotes While monoclonal antibodies tend to have a higher degree of selectivity, they are more expensive and take longer to develop than polyclonal antibodies.
T506 577-713 Sentence denotes Polyclonal antibodies are produced by separation of immunoglobulin proteins from the blood of an infected host (Birch and Racher, 2006).
T507 714-782 Sentence denotes Polyclonal antibodies target different epitopes on a single antigen.
T508 783-999 Sentence denotes While polyclonal antibodies exhibit increased variability between batches, they are relatively less expensive to produce than monoclonal antibodies and facilitate robust measurements in various settings (Byrne et al.
T509 1000-1006 Sentence denotes 2009).
T510 1007-1122 Sentence denotes Drawbacks to antibody use include high cost and stability challenges, such as the need for low-temperature storage.
T511 1123-1254 Sentence denotes As shown in Table 1, Table 2, both monoclonal and polyclonal antibodies are used as biorecognition elements for pathogen detection.
T512 1255-1526 Sentence denotes For assays involving secondary binding steps, monoclonal antibodies typically serve as the primary biorecognition element and are immobilized on the electrode, while polyclonal antibodies serve as the secondary biorecognition element and often facilitate target labeling.
T513 1527-1690 Sentence denotes For assays that do not require secondary binding steps, polyclonal antibodies are also commonly used as immobilized biorecognition elements for pathogen detection.
T514 1691-1899 Sentence denotes For example, Pandey et al. immobilized monoclonal anti-E. coli on a composite nanostructured electrode to detect E. coli across a wide dynamic range of 10 to 108 CFU/mL with a LOD of 3.8 CFU/mL (Pandey et al.
T515 1900-1906 Sentence denotes 2017).
T516 1907-2036 Sentence denotes Wu et al. used polyclonal anti-E. coli for detection of E. coli via amperometry that exhibited a LOD of 5 × 103 CFU/mL (Wu et al.
T517 2037-2043 Sentence denotes 2016).
T518 2044-2305 Sentence denotes Lin et al. used monoclonal antibodies for detection of avian influenza virus H5N1 in chicken swabs across a dynamic range of 2- 1 to 24 hemagglutination units (HAU)/50 μL using EIS and the ferri/ferrocyanide (Fe(CN)6 3 - /4-) couple as a redox probe (Lin et al.
T519 2306-2312 Sentence denotes 2015).
T520 2313-2451 Sentence denotes Luka et al. detected Cryptosporidium parvum (C. parvum) with a LOD of 40 cells/mm2 via capacitive sensing and Fe(CN)6 3 - /4- (Luka et al.
T521 2452-2458 Sentence denotes 2019).