LitCovid-sentences  

PMC:7152526 / 6432-9714 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T56 0-6 Sentence denotes Case 2
T57 7-154 Sentence denotes A 67-year-old woman with a medical history of hypertension developed fever and myalgia and diagnosed as COVID-19 via SARS-CoV-2 rRT-PCR on March 6.
T58 155-346 Sentence denotes The next day, she was admitted to a local public medical center and received hydroxychloroquine 400 mg once daily and lopinavir/ritonavir 400 mg/100 mg twice daily with empirical antibiotics.
T59 347-505 Sentence denotes However, on day 3, she was transferred to the tertiary-care hospital due to increased oxygen demand and worsening infiltrative shadows in the left lower lung.
T60 506-642 Sentence denotes At that time, her oxygen saturation checked 93% on 4 L/min oxygen flow via nasal cannula with a respiratory rate of 24 times per minute.
T61 643-900 Sentence denotes Routine blood tests showed mild leukocytosis (12.67 × 103/µL) with lymphopenia (0.7 × 103/µL), elevated CRP, IL-6 and LDH. (131.1 mg/L, 474.7 pg/mL, 344 IU/L, respectively) Routine chemistry, electrolyte, and blood coagulation tests showed no abnormalities.
T62 901-980 Sentence denotes Bacterial cultures and the PCR for other respiratory viruses were all negative.
T63 981-1143 Sentence denotes She received high flow oxygen therapy but bilateral infiltration and oxygenation were deteriorated, so intubation and mechanical ventilator care started on day 4.
T64 1144-1212 Sentence denotes Intravenous methylprednisolone (0.5 mg/kg/day daily) was also added.
T65 1213-1346 Sentence denotes She had sustained high fever with rapidly increasing CRP (314 mg/L), WBC (21.79 × 103/µL), and persistent lymphopenia (0.5 × 103/µL).
T66 1347-1397 Sentence denotes PaO2/FiO2 fell to 76, consistent with severe ARDS.
T67 1398-1554 Sentence denotes After applying for the prone position according to the management of ARDS with the use of steroids, chest images and the oxygen demand began to be improved.
T68 1555-1671 Sentence denotes On day 6, convalescent plasma was obtained from a male donor in his 20s who had recovered from COVID-19 for 18 days.
T69 1672-1847 Sentence denotes He was diagnosed as COVID-19 presenting fever, cough and pneumonia however, showed complete recovery and serial PCRs for SARS-CoV-2 were all negative after hospital discharge.
T70 1848-1934 Sentence denotes Donor screening and plasma collection were performed as mentioned above in the Case 1.
T71 1935-2035 Sentence denotes OD ratio for IgG was 0.532 and the plasma was administered to the patient in the same way as Case 1.
T72 2036-2096 Sentence denotes There was no adverse reaction during the plasma transfusion.
T73 2097-2188 Sentence denotes Leukocytosis and lymphopenia were immediately recovered after convalescent plasma infusion.
T74 2189-2298 Sentence denotes On day 9, the density of bilateral infiltration on chest X-ray much improved with increased PaO2/FiO2 to 230.
T75 2299-2366 Sentence denotes The level of CRP and IL-6 also recovered to the normal range (Figs.
T76 2367-2376 Sentence denotes 3 and 4).
T77 2377-2508 Sentence denotes SARS-CoV-2 was quantified by rRT-PCR; the value of Ct changed from 20.51 on day 5 to 36.33 on day 9 after plasma infusion (Fig. 3).
T78 2509-2590 Sentence denotes The patient is successfully extubated and discharged from the hospital on day 24.
T79 2591-2628 Sentence denotes SARS-CoV-2 was negative after day 20.
T80 2629-2975 Sentence denotes Fig. 3 Case 2, responses to treatment. (A) Timelines of changes in PaO2/FiO2 and CRP during hospitalization. (B) Timelines of detection of the RNA-dependent RNA polymerase region of the ORF1b gene of severe acute respiratory syndrome coronavirus-2 in sputum by real-time reverse transcription polymerase chain reaction; cycle threshold is shown.
T81 2976-3001 Sentence denotes CRP = C-reactive protein.
T82 3002-3085 Sentence denotes Fig. 4 Chest X-rays of Case 2 taken before and after convalescent plasma infusion.
T83 3086-3149 Sentence denotes Taken on day 2, before the convalescent plasma infusion (left).
T84 3150-3225 Sentence denotes Taken on day 6 shows marked improvement of bilateral infiltrations (right).
T85 3226-3282 Sentence denotes The images are published under agreement of the patient.