LitCovid-sentences  

PMC:7152526 / 2022-6430 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T17 0-6 Sentence denotes Case 1
T18 7-134 Sentence denotes A previously healthy 71-year-old man visited the Community Health Center on February 22, presenting 12 days of fever and cough.
T19 135-275 Sentence denotes He underwent an examination of SARS-CoV-2 via real-time reverse transcription polymerase chain reaction (rRT-PCR) and diagnosed as COVID-19.
T20 276-379 Sentence denotes He admitted to the local public medical center and 400 mg of hydroxychloroquine once daily was started.
T21 380-520 Sentence denotes A chest radiograph obtained on day 2 showed mild opacities in the right lower lung, lopinavir/ritonavir 400 mg/100 mg twice daily was added.
T22 521-613 Sentence denotes However, on day 3, oxygen demand increased, so he transferred to the tertiary-care hospital.
T23 614-775 Sentence denotes At the time of arrival, the patient had no subjective dyspnea under 4 L/min oxygen flow via nasal cannula, but the respiratory rate was over 30 times per minute.
T24 776-849 Sentence denotes Chest radiographs demonstrated rapidly aggravated bilateral infiltration.
T25 850-956 Sentence denotes Routine blood tests found white blood cell (WBC) count at 3.53 × 103/µL, with lymphopenia of 0.4 × 103/µL.
T26 957-1051 Sentence denotes C-reactive protein (CRP) and lactic dehydrogenase (LDH) elevated up to 59.7 mg/L and 814 IU/L.
T27 1052-1184 Sentence denotes Routine chemistry, electrolyte, and blood coagulation tests revealed no abnormalities except mildly elevated aspartate transaminase.
T28 1185-1248 Sentence denotes The level of interleukin 6 (IL-6) was increased as 101.3 pg/mL.
T29 1249-1358 Sentence denotes Serial bacterial culture and polymerase chain reaction (PCR) for other respiratory viruses were all negative.
T30 1359-1450 Sentence denotes Intubation and mechanical ventilator care were started according to the management of ARDS.
T31 1451-1622 Sentence denotes Despite the continuous use of lopinavir/ritonavir, hydroxychloroquine and empirical antibiotics, he remained febrile with aggravated oxygenation profiles and chest images.
T32 1623-1704 Sentence denotes Laboratory test showed further elevation of CRP (172.6 mg/L), IL-6 (208.2 pg/mL).
T33 1705-1799 Sentence denotes On day 9, the arterial blood gas analysis showed PaO2/FiO2 of 86, consistent with severe ARDS.
T34 1800-1863 Sentence denotes Intravenous methylprednisolone (1 mg/kg/day daily) was started.
T35 1864-1981 Sentence denotes On day 10, convalescent plasma was obtained from a male donor in his 20s who had recovered from COVID-19 for 21 days.
T36 1982-2143 Sentence denotes He was diagnosed as COVID-19 presenting fever, cough and pneumonia, however, showed complete recovery and didn’t have any symptom at the time of plasma donation.
T37 2144-2271 Sentence denotes He has met the blood donor eligibility criteria for plasma donation, including age, weight, reasonable-sized antecubital veins.
T38 2272-2411 Sentence denotes Also, allogeneic donor screening tests, defined by enforcement rules of the Blood Management Act in Korea, were acceptable for transfusion.
T39 2412-2600 Sentence denotes Donor apheresis was performed with Spectra Optia apheresis system (CMNC software; Spectra Optia IDL Tubing set; Terumo BCT, Lakewood, CO, USA), 500 mL of convalescent plasma was collected.
T40 2601-2852 Sentence denotes Anti-SARS-CoV-2 IgG antibody in plasma was measured by enzyme-linked immunosorbent assay (ELISA) (Novel Coronavirus COVID-19 IgG ELISA kit; Epitope Diagnostics, San Diego, CA, USA) and optical density (OD) ratio for IgG was 0.586 (cut-off value 0.22).
T41 2853-2944 Sentence denotes The plasma was divided into two doses and administered to the patient at 12 hours interval.
T42 2945-2981 Sentence denotes Each dose was given over for 1 hour.
T43 2982-3059 Sentence denotes No adverse reaction occurred after the administration of convalescent plasma.
T44 3060-3121 Sentence denotes The fever subsided, and oxygen demand decreased since day 11.
T45 3122-3300 Sentence denotes The patient's condition much improved with decreased CRP and IL-6 to normal range (5.7 mg/L and < 1.5 pg/mL, respectively), and on day 18, PaO2/FiO2 increased up to 300 (Fig. 1).
T46 3301-3377 Sentence denotes A chest X-ray revealed further resolution of both lung infiltrates (Fig. 2).
T47 3378-3603 Sentence denotes SARS-CoV-2 was quantified by detection of the RNA-dependent RNA polymerase region of the ORF1b gene on rRT-PCR, the value of cycle threshold (Ct) changed from 24.98 on day 10 to 33.96 on day 20 after plasma infusion (Fig. 1).
T48 3604-3641 Sentence denotes SARS-CoV-2 was negative after day 26.
T49 3642-3748 Sentence denotes The patient underwent a tracheostomy and currently, is successfully weaned from the mechanical ventilator.
T50 3749-4095 Sentence denotes Fig. 1 Case 1, responses to treatment. (A) Timelines of changes in PaO2/FiO2 and CRP during hospitalization. (B) Timelines of detection of the RNA-dependent RNA polymerase region of the ORF1b gene of severe acute respiratory syndrome coronavirus-2 in sputum by real-time reverse transcription polymerase chain reaction; cycle threshold is shown.
T51 4096-4121 Sentence denotes CRP = C-reactive protein.
T52 4122-4205 Sentence denotes Fig. 2 Chest X-rays of Case 1 taken before and after convalescent plasma infusion.
T53 4206-4274 Sentence denotes Taken on day 7, just before the convalescent plasma infusion (left).
T54 4275-4351 Sentence denotes Taken on day 13 shows marked improvement of bilateral infiltrations (right).
T55 4352-4408 Sentence denotes The images are published under agreement of the patient.