LitCovid-sentences  

PMC:7148425 / 4902-7058 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T28 0-46 Sentence denotes Immunosenescence and its underlying mechanisms
T29 47-201 Sentence denotes Altered immune competence with increasing age, so-called immunosenescence [6], is the result of changes at multiple levels of the immune system over time.
T30 202-400 Sentence denotes It includes the altered balance of immune cell production in the bone marrow resulting in reduced lymphopoiesis and increased output of myeloid lineage cells which are also functionally compromised.
T31 401-512 Sentence denotes Thymic involution substantially reduces the output of naïve T cells and the TCR repertoire contracts over time.
T32 513-659 Sentence denotes Although loss of circulating naïve B cells is less profound than naïve T cells, reduced BCR repertoire diversity with age is also well recognized.
T33 660-892 Sentence denotes Furthermore, aging is associated with the dysfunction of innate immune cells like neutrophils at sites of infection possibly due to the poorer capacity of the adaptive immune system to reign in over-exuberant inflammatory responses.
T34 893-1055 Sentence denotes The ability to generate adaptive immune responses is compromised by dysfunction of antigen-presenting cells and disorganised and fibrotic lymph node architecture.
T35 1056-1318 Sentence denotes Collectively, these changes prevent appropriate control of the initial inflammatory response and decrease the generation of an efficient and robust adaptive immune response which requires the production of large number of functional effector T cells and B cells.
T36 1319-1608 Sentence denotes For all these reasons, protective responses to infection or vaccination tend to be on average lower in many older adults than in the young, but there is enormous inter-individual variation in people owing to the individual variations of genetics and the history of environmental exposures.
T37 1609-1673 Sentence denotes Hence, two crucial questions are raised by these considerations:
T38 1674-1898 Sentence denotes 1) how can we measure immune and physiological status in an individual in a clinically meaningful manner and 2) how can we intervene at the crucial checkpoints thus identified in order to restore appropriate immune function?
T39 1899-2156 Sentence denotes Identification of biomarkers of protective or detrimental responses to a SARS-CoV-2 infection or vaccine and determination of the kinetic pattern of these biomarkers during the course of infection or vaccine response are critical to address these questions.