LitCovid-sentences  

PMC:7148425 / 2581-4900 JSONTXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T16 0-181 Sentence denotes There is no pre-existing immunity to a virus not previously encountered except via cross-reactivity or shared viral antigen, as is sometimes the case for seasonal influenza strains.
T17 182-411 Sentence denotes As SARS-CoV-2 is almost certainly completely novel for at least the vast majority of people, the virus enjoys unrestrained entry into host cells which then rely on intracellular (cell-intrinsic) anti-viral defence mechanisms [4].
T18 412-537 Sentence denotes If these fail, cell death releases damage-associated molecules (DAMPs) and viral particles triggering inflammatory reactions.
T19 538-837 Sentence denotes Severe acute respiratory syndrome is caused by dysregulated over-exuberant inflammatory responses that can progress to a systemic sepsis-like “cytokine storm” [5], which together with effects of the virus also directly infecting other organs, not just the lung, can result in multiple organ failure.
T20 838-1067 Sentence denotes The aim of prophylactic vaccination of course is to induce sufficient neutralising antibody to prevent infection and sufficient numbers of virus-specific resident memory cytotoxic T cells in the lung to prevent viral replication.
T21 1068-1231 Sentence denotes This requires the presence and efficient cooperation of antigen-presenting cells, T cells and B cells within a correctly functioning microenvironment (lymph node).
T22 1232-1417 Sentence denotes When vaccination is unable to elicit qualitatively or quantitatively sufficient protective antibody, host cell infection will still take place, and may trigger sequelae described above.
T23 1418-1674 Sentence denotes Given the rapidity and degree with which SARS-CoV-2 can cause immunopathology in the lung, vaccines would have to be highly efficient in generating neutralising antibody as well as protective cell mediated local immunity to prevent this sequence of events.
T24 1675-1890 Sentence denotes Achieving such immune protection by a vaccine is quite feasible in the young, but it may prove to be challenging in old populations as evidenced by the low efficacy of seasonal influenza vaccine in such populations.
T25 1891-2056 Sentence denotes Alternatively, adoptive immunotherapy with neutralising monoclonal antibody, as in cancer treatment, may be a possibility, and several companies are working on this.
T26 2057-2155 Sentence denotes However, repeated i.v. infusion of sufficient antibody does not seem a priori an optimal approach.
T27 2156-2319 Sentence denotes Clearly, traditional vaccination to stimulate the patient’s own response would be preferable, but how likely is it that that could be accomplished in older people?