LitCovid-sentences  

PMC:7143804 / 6685-8195 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T58 0-109 Sentence denotes There are various materials that can be used to fabricate lab-on-a-chip devices for DNA or RNA amplification.
T59 110-245 Sentence denotes In the past 15 years, more than ten polymers, ceramic materials, and metals have successfully been used to fabricate such devices [15].
T60 246-325 Sentence denotes The major property playing a role here is the biocompatibility of the material.
T61 326-414 Sentence denotes The surface of the microfluidic structure should not inhibit the amplification reaction.
T62 415-568 Sentence denotes This biocompatibility can be an intrinsic property of the material or the surface can be modified or coated to achieve this [12,13,14,15,16,17,18,19,20].
T63 569-699 Sentence denotes One often used material is polydimethylsiloxane (PDMS) [22,23,31,32,34,35,38], which can be processed using soft lithography [39].
T64 700-817 Sentence denotes However, this is a fabrication technology used in academia and is not suitable for upscaling to mass production [40].
T65 818-921 Sentence denotes Fabrication methods suitable for mass production are thermoforming/embossing or injection molding [41].
T66 922-1141 Sentence denotes One of the materials which is biocompatible and suitable for both industrial scale fabrication technologies is cyclic olefin copolymer (COC) [42], which is one of the materials used in the past as well [28,36,43,44,45].
T67 1142-1322 Sentence denotes Guckenberger et al. estimates the costs of injection molding of only 50 simple microfluidic devices on $47, but this becomes cheaper when the mass production stage is reached [41].
T68 1323-1396 Sentence denotes Another benefit of COC is the possibility to shape it using micromilling.
T69 1397-1510 Sentence denotes This technique is a rapid prototyping technology and therefore very useful within proof-of-concept projects [41].