PMC:7143804 / 21974-23731 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T171 0-172 Sentence denotes COC [42] is chosen as polymeric substrate because of its biocompatibility, optical transparency, physical resistance, chemical resistance, electrical insulation, and price.
T172 173-324 Sentence denotes This copolymer consists of two monomers, an apolar bridged cyclic hydrocarbon (norbornene) monomer and a linear, lesser apolar, linear ethene monomers.
T173 325-520 Sentence denotes Injection molded COC plates (10 cm by 10 cm and 1.5 mm thickness) of the grade TOPAS 6017 (see Figure 4a) are obtained via Kunststoff-Zentrum Leipzig (Kunststoff-Zentrum gGmbH, Leipzig, Germany).
T174 521-623 Sentence denotes This grade is chosen because of its high norbornene content, giving it a relatively high Tg of 170 °C.
T175 624-796 Sentence denotes This minimizes the chance of melting during the milling process and decreases the chance of heater failure due to a deforming substrate during operation of the heater [28].
T176 797-966 Sentence denotes The microfluidic structure explained in Section 2.1 is CNC-milled using a Mikron WF 21C milling machine (Mikron SA Agno, Agno, Switzerland), as can be seen in Figure 4b.
T177 967-1055 Sentence denotes Milling is a very fast prototyping technique and chosen because of its flexibility [41].
T178 1056-1146 Sentence denotes The milling creates a surface roughness, which increases the surface-area-to-volume ratio.
T179 1147-1289 Sentence denotes This roughness increases the chance of inhibition during the amplification due to the interaction of the used chemicals with the surface [44].
T180 1290-1441 Sentence denotes It also causes a considerable loss of optical transparency, which could obstruct the potential use of in situ fluorescence detection in future devices.
T181 1442-1526 Sentence denotes Therefore, a chemical post-treatment with cyclohexane vapor is done (see Figure 4c).
T182 1527-1757 Sentence denotes Such treatment dissolves a thin outer layer of the COC substrate and causes reflowing of the surface roughness due to the surface tension of the material, restoring the optical transparency and reducing the surface roughness [59].